Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

18 Scopus Citations
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Author(s)

  • Jangsun Hwang
  • Mengjia Zheng
  • Christian Wiraja
  • Mingyue Cui
  • Lixia Yang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)5254-5262
Journal / PublicationNanoscale Advances
Volume2
Issue number11
Online published9 Sept 2020
Publication statusPublished - 1 Nov 2020

Link(s)

Abstract

Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.

Research Area(s)

Citation Format(s)

Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts. / Hwang, Jangsun; Zheng, Mengjia; Wiraja, Christian et al.
In: Nanoscale Advances, Vol. 2, No. 11, 01.11.2020, p. 5254-5262.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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