Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 5254-5262 |
| Journal / Publication | Nanoscale Advances |
| Volume | 2 |
| Issue number | 11 |
| Online published | 9 Sep 2020 |
| Publication status | Published - 1 Nov 2020 |
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| DOI | DOI |
|---|---|
| Attachment(s) | Documents
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| Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85096037066&origin=recordpage |
| Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(99c8e44a-9de5-4b95-81e2-0fa4a1df2b01).html |
Abstract
Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.
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Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts. / Hwang, Jangsun; Zheng, Mengjia; Wiraja, Christian et al.
In: Nanoscale Advances, Vol. 2, No. 11, 01.11.2020, p. 5254-5262.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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