Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

Jangsun Hwang; Mengjia Zheng; Christian Wiraja; Mingyue Cui; Lixia Yang; Chenjie Xu

doi:10.1039/d0na00572j

Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

Jangsun Hwang, Mengjia Zheng, Christian Wiraja, Mingyue Cui, Lixia Yang, Chenjie Xu^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

25 Citations (Scopus)

58 Downloads (CityUHK Scholars)

Abstract

Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.

Original language	English
Pages (from-to)	5254-5262
Journal	Nanoscale Advances
Volume	2
Issue number	11
Online published	9 Sept 2020
DOIs	https://doi.org/10.1039/d0na00572j
Publication status	Published - 1 Nov 2020

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This full text is made available under CC-BY-NC 3.0. https://creativecommons.org/licenses/by-nc/3.0/

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abstract = "Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.",

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AU - Zheng, Mengjia

AU - Wiraja, Christian

AU - Cui, Mingyue

AU - Yang, Lixia

AU - Xu, Chenjie

PY - 2020/11/1

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N2 - Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.

AB - Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.

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M3 - RGC 21 - Publication in refereed journal

C2 - 36132036

SN - 2516-0230

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SP - 5254

EP - 5262

JO - Nanoscale Advances

JF - Nanoscale Advances

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Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

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