Abstract
Mini Chromosome Maintenance proteins (MCMs) are replicative helicases essential for DNA replication. Interestingly, MCM proteins are present in large excess relative to the number of origins of replication, suggesting the MCMs may involve in other cellular functions. Indeed, a recent study from Hubbi et al. has demonstrated the direct role of MCM3 and MCM7 in regulating HIF1. Previous study from us has identified MCM3 as one of the potential factors for the maintenance of X chromosome inactivation (XCI) from a genome wide shRNA screen. In this talk I will present the data showing the chromatin function of MCM3 that is independent of DNA replication.
| Original language | English |
|---|---|
| Publication status | Published - 25 Jul 2016 |
| Event | Gordon Research Conference : Genomic Instability - University of Science and Technology, Hong Kong, Hong Kong, China Duration: 25 Jul 2016 → 29 Jul 2016 https://www.grc.org/programs.aspx?id=16810 |
Conference
| Conference | Gordon Research Conference |
|---|---|
| Place | Hong Kong, China |
| City | Hong Kong |
| Period | 25/07/16 → 29/07/16 |
| Internet address |
Research Keywords
- DNA Packaging, Replication, and Repair
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