Replication Independent Chromatin Function of MCM3

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)31A_Invited conference paper (refereed items)Invited

View graph of relations

Author(s)

Related Research Unit(s)

Detail(s)

Original languageEnglish
Publication statusPublished - 25 Jul 2016

Conference

TitleGordon Research Conference
LocationUniversity of Science and Technology
PlaceHong Kong
CityHong Kong
Period25 - 29 July 2016

Abstract

Mini Chromosome Maintenance proteins (MCMs) are replicative helicases essential for DNA replication. Interestingly, MCM proteins are present in large excess relative to the number of origins of replication, suggesting the MCMs may involve in other cellular functions. Indeed, a recent study from Hubbi et al. has demonstrated the direct role of MCM3 and MCM7 in regulating HIF1. Previous study from us has identified MCM3 as one of the potential factors for the maintenance of X chromosome inactivation (XCI) from a genome wide shRNA screen. In this talk I will present the data showing the chromatin function of MCM3 that is independent of DNA replication.

Research Area(s)

  • DNA Packaging, Replication, and Repair

Citation Format(s)

Replication Independent Chromatin Function of MCM3. / CHAN, Kui Ming.

2016. Gordon Research Conference , Hong Kong, Hong Kong.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)31A_Invited conference paper (refereed items)Invited