Renal and vascular function in pregnant and neonatal rats exposed to melamine and related compounds

W. T. Wong; X. Y. Tian; C. W. Lau; Y. X. Wang; J. Liu; W. S. Cheang; Z. Y. Chen; C. S. Mok; C. M. Lau; Yu Huang

Renal and vascular function in pregnant and neonatal rats exposed to melamine and related compounds

W. T. Wong
, X. Y. Tian
, C. W. Lau
, Y. X. Wang
, J. Liu
, W. S. Cheang
, Z. Y. Chen
, C. S. Mok
, C. M. Lau
, Yu Huang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

3 Citations (Scopus)

Abstract

1. In rats, long-term exposure to melamine impairs renal blood flow and renal vascular function in a dose-dependent manner.
2. Melamine-induced renal vascular dysfunction is caused by enhanced vasoconstriction and reduced vasodilatation owing to the endothelial cell dysfunction of renal arteries.
3. Endothelial dysfunction after melamine treatment is mediated through oxidative stress- dependent activation and up- regulation of cyclooxygenase 2, which produces prostanoids that act on the thromboxane receptor.
4. Transforming growth factor β1 and bone morphogenic protein 4 contribute to renal fibrosis induced by oral administration of melamine.
5. Exposure to melamine during pregnancy and lactation exaggerates renal vascular dysfunction in the offspring.

Original language	English
Pages (from-to)	S31-S33
Journal	Hong Kong Medical Journal
Volume	19
Issue number	6 (Supplement 8)
Publication status	Published - Dec 2013
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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@article{20ae53cc9b0a47a38a1cbb01da3f4ed5,

title = "Renal and vascular function in pregnant and neonatal rats exposed to melamine and related compounds",

abstract = "1. In rats, long-term exposure to melamine impairs renal blood flow and renal vascular function in a dose-dependent manner. 2. Melamine-induced renal vascular dysfunction is caused by enhanced vasoconstriction and reduced vasodilatation owing to the endothelial cell dysfunction of renal arteries. 3. Endothelial dysfunction after melamine treatment is mediated through oxidative stress- dependent activation and up- regulation of cyclooxygenase 2, which produces prostanoids that act on the thromboxane receptor. 4. Transforming growth factor β1 and bone morphogenic protein 4 contribute to renal fibrosis induced by oral administration of melamine. 5. Exposure to melamine during pregnancy and lactation exaggerates renal vascular dysfunction in the offspring.",

author = "Wong, \{W. T.\} and Tian, \{X. Y.\} and Lau, \{C. W.\} and Wang, \{Y. X.\} and J. Liu and Cheang, \{W. S.\} and Chen, \{Z. Y.\} and Mok, \{C. S.\} and Lau, \{C. M.\} and Yu Huang",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

year = "2013",

month = dec,

language = "English",

volume = "19",

pages = "S31--S33",

journal = "Hong Kong Medical Journal",

issn = "1024-2708",

publisher = "Hong Kong Academy of Medicine Press",

number = "6 (Supplement 8)",

}

TY - JOUR

T1 - Renal and vascular function in pregnant and neonatal rats exposed to melamine and related compounds

AU - Wong, W. T.

AU - Tian, X. Y.

AU - Lau, C. W.

AU - Wang, Y. X.

AU - Liu, J.

AU - Cheang, W. S.

AU - Chen, Z. Y.

AU - Mok, C. S.

AU - Lau, C. M.

AU - Huang, Yu

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2013/12

Y1 - 2013/12

N2 - 1. In rats, long-term exposure to melamine impairs renal blood flow and renal vascular function in a dose-dependent manner. 2. Melamine-induced renal vascular dysfunction is caused by enhanced vasoconstriction and reduced vasodilatation owing to the endothelial cell dysfunction of renal arteries. 3. Endothelial dysfunction after melamine treatment is mediated through oxidative stress- dependent activation and up- regulation of cyclooxygenase 2, which produces prostanoids that act on the thromboxane receptor. 4. Transforming growth factor β1 and bone morphogenic protein 4 contribute to renal fibrosis induced by oral administration of melamine. 5. Exposure to melamine during pregnancy and lactation exaggerates renal vascular dysfunction in the offspring.

AB - 1. In rats, long-term exposure to melamine impairs renal blood flow and renal vascular function in a dose-dependent manner. 2. Melamine-induced renal vascular dysfunction is caused by enhanced vasoconstriction and reduced vasodilatation owing to the endothelial cell dysfunction of renal arteries. 3. Endothelial dysfunction after melamine treatment is mediated through oxidative stress- dependent activation and up- regulation of cyclooxygenase 2, which produces prostanoids that act on the thromboxane receptor. 4. Transforming growth factor β1 and bone morphogenic protein 4 contribute to renal fibrosis induced by oral administration of melamine. 5. Exposure to melamine during pregnancy and lactation exaggerates renal vascular dysfunction in the offspring.

UR - https://www.scopus.com/pages/publications/84906318618

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84906318618&origin=recordpage

M3 - RGC 21 - Publication in refereed journal

C2 - 24473526

SN - 1024-2708

VL - 19

SP - S31-S33

JO - Hong Kong Medical Journal

JF - Hong Kong Medical Journal

IS - 6 (Supplement 8)

ER -

Renal and vascular function in pregnant and neonatal rats exposed to melamine and related compounds

Abstract

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