Renal and vascular function in pregnant and neonatal rats exposed to melamine and related compounds
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | S31-S33 |
| Journal / Publication | Hong Kong Medical Journal |
| Volume | 19 |
| Issue number | 6 (Supplement 8) |
| Publication status | Published - Dec 2013 |
| Externally published | Yes |
Link(s)
| Document Link | Links
|
|---|---|
| Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-84906318618&origin=recordpage |
| Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(20ae53cc-9b0a-47a3-8a1c-bb01da3f4ed5).html |
Abstract
1. In rats, long-term exposure to melamine impairs renal blood flow and renal vascular function in a dose-dependent manner.
2. Melamine-induced renal vascular dysfunction is caused by enhanced vasoconstriction and reduced vasodilatation owing to the endothelial cell dysfunction of renal arteries.
3. Endothelial dysfunction after melamine treatment is mediated through oxidative stress- dependent activation and up- regulation of cyclooxygenase 2, which produces prostanoids that act on the thromboxane receptor.
4. Transforming growth factor β1 and bone morphogenic protein 4 contribute to renal fibrosis induced by oral administration of melamine.
5. Exposure to melamine during pregnancy and lactation exaggerates renal vascular dysfunction in the offspring.
2. Melamine-induced renal vascular dysfunction is caused by enhanced vasoconstriction and reduced vasodilatation owing to the endothelial cell dysfunction of renal arteries.
3. Endothelial dysfunction after melamine treatment is mediated through oxidative stress- dependent activation and up- regulation of cyclooxygenase 2, which produces prostanoids that act on the thromboxane receptor.
4. Transforming growth factor β1 and bone morphogenic protein 4 contribute to renal fibrosis induced by oral administration of melamine.
5. Exposure to melamine during pregnancy and lactation exaggerates renal vascular dysfunction in the offspring.
Bibliographic Note
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Citation Format(s)
Renal and vascular function in pregnant and neonatal rats exposed to melamine and related compounds. / Wong, W. T.; Tian, X. Y.; Lau, C. W. et al.
In: Hong Kong Medical Journal, Vol. 19, No. 6 (Supplement 8), 12.2013, p. S31-S33.
In: Hong Kong Medical Journal, Vol. 19, No. 6 (Supplement 8), 12.2013, p. S31-S33.
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
