Remote Regulation of Optogenetic Proteins by a Magneto-Luminescence Microdevice

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yingying Zhang
  • Hanjie Wang
  • Yu Tian
  • Huizhuo Pan
  • Lili Zhang
  • Jin Chang

Detail(s)

Original languageEnglish
Article number2006357
Journal / PublicationAdvanced Functional Materials
Volume31
Issue number4
Online published21 Oct 2020
Publication statusPublished - 22 Jan 2021

Abstract

Mechanoluminescence (ML) is characterized by photon emission under mechanical action, which is promising for biomedical applications, such as stress sensing and artificial skin. However, the use of ML in deep tissues has encountered a bottleneck due to the need for contact excitation. In this paper, a magneto-luminescence microdevice (MLMD) is devised to realize optical emission through non-contact excitation of a rotating magnetic field. The MLMD is composed of ML materials (lanthanide-doped CaZnOS crystals) and a magnet bar, in which the magnet bar can collect excitation energy of the magnetic field and then drive the ML materials to emit light by rotational motion. The optical emission of the MLMD is used to remotely stimulate two optogenetic models at different tissue depths, including subcutaneous photodynamic therapy of tumor and neuromodulation of behaving mice. This work establishes an innovative approach to achieve remote control of light delivery, which is expected to inspire new applications in biomedicine.

Research Area(s)

  • magneto stimulation, mechanoluminescence, neuromodulation, optogenetics, tumor therapy

Citation Format(s)

Remote Regulation of Optogenetic Proteins by a Magneto-Luminescence Microdevice. / Zhang, Yingying; Zhang, Xin; Wang, Hanjie; Tian, Yu; Pan, Huizhuo; Zhang, Lili; Wang, Feng; Chang, Jin.

In: Advanced Functional Materials, Vol. 31, No. 4, 2006357, 22.01.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review