Relayed nuclear Overhauser effect (rNOE) imaging identifies multiple sclerosis : an initial human study

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)peer-review

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Author(s)

  • Jianpan Huang
  • Jiadi Xu
  • Henry K. F. Mak
  • Koon Ho Chan

Detail(s)

Original languageEnglish
Publication statusPublished - May 2021

Conference

Title2021 International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting
LocationOnline
Period15 - 20 May 2021

Abstract

Multiple sclerosis (MS) is demyelinating disease of the central nervous system (CNS), which affects more than two million people globally. Here we applied our optimized pulsed-CEST MRI method to acquire relayed nuclear Overhauser effect weighted (rNOEw) images for detecting the pathology changes regarding myelin lipid/protein in human brain with neuromyelitis optica (NMO) and MS on clinical 3T scanner. We found that rNOEw signal of MS brains was significantly lower than that of NMO and NC brains. Our proposed rNOEw imaging method has great potential to assist MS diagnosis and specifically identify MS patients from NMO patients.

Bibliographic Note

Information for this record is supplemented by the author(s) concerned.

Citation Format(s)

Relayed nuclear Overhauser effect (rNOE) imaging identifies multiple sclerosis : an initial human study. / Huang, Jianpan; Xu, Jiadi; Lai, Joseph H. C.; Mak, Henry K. F.; Chan, Koon Ho; Chan, Kannie W. Y.

2021. Paper presented at 2021 International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting, .

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)peer-review