TY - JOUR
T1 - Relationship between periodic dinucleotides and the nucleosome structure revealed by alpha shape modeling
AU - Zhou, Weiqiang
AU - Yan, Hong
PY - 2010/4/9
Y1 - 2010/4/9
N2 - As the fundamental repeating units in eukaryotic chromatin, nucleosomes play an important role in many biological processes. For this reason, the study of the structure of nucleosomes may help to reveal some of the crucial principals of these processes. In our research, we have used alpha shapes to model nucleosome structure and discovered that the periodic DNA dinucleotides AA, TT and GC occupy special positions in nucleosome structure with one nucleotide inside and the other outside the nucleosome surface. This structural feature and other dinucleotide characteristics can provide useful information for the study of nucleosome positioning. © 2010 Elsevier B.V. All rights reserved.
AB - As the fundamental repeating units in eukaryotic chromatin, nucleosomes play an important role in many biological processes. For this reason, the study of the structure of nucleosomes may help to reveal some of the crucial principals of these processes. In our research, we have used alpha shapes to model nucleosome structure and discovered that the periodic DNA dinucleotides AA, TT and GC occupy special positions in nucleosome structure with one nucleotide inside and the other outside the nucleosome surface. This structural feature and other dinucleotide characteristics can provide useful information for the study of nucleosome positioning. © 2010 Elsevier B.V. All rights reserved.
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U2 - 10.1016/j.cplett.2010.02.074
DO - 10.1016/j.cplett.2010.02.074
M3 - RGC 21 - Publication in refereed journal
SN - 0009-2614
VL - 489
SP - 225
EP - 228
JO - Chemical Physics Letters
JF - Chemical Physics Letters
IS - 4-6
ER -