Abstract
The transient receptor potential (TRP) channels are a group of Ca 2+-permeable cation channels (except TRPM4 and TRPM5) that function as cellular sensors of various internal and external stimuli. Most of these channels are expressed in the nervous system and they play a key role in sensory physiology. They may respond to temperature, pressure, inflammatory agents, pain, osmolarity, taste and many other stimuli. Recent development indicates that the activity of these channels is regulated by protein phosphorylation and dephosphorylation of serine, threonine, and tyrosine residues. In this review, we present a comprehensive summary of the literature regarding the TRP channel regulation by different protein kinases. Copyright © 2005 S. Karger AG.
| Original language | English |
|---|---|
| Pages (from-to) | 273-280 |
| Journal | NeuroSignals |
| Volume | 14 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2006 |
| Externally published | Yes |
Bibliographical note
Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].Research Keywords
- Ca2+ influx
- Phosphorylation
- TRP channels