Regulation of TiO2 nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation

Ruoyu Li; Hongyu Zhang; Xiaohong Yao; Bin Tang; Paul K Chu; Xiangyu Zhang

doi:10.1016/j.jmst.2022.12.023

Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation

Ruoyu Li, Hongyu Zhang, Xiaohong Yao, Bin Tang^*, Paul K Chu, Xiangyu Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

12 Citations (Scopus)

Abstract

The surface topography of implants plays a major role in osteogenesis and immunomodulation. In this study, three types of TiO₂ nanoarrays including nanorod arrays with a diameter of 45 nm (TiO₂-N), nanorod arrays with a diameter of 60 nm (TiO₂-N N), and nanocone arrays (TiO₂-NW) are prepared on titanium and the behavior of bone marrow stromal cells (BMSCs) and polarization of macrophages are studied. Compared to the planar titanium control, TiO₂ nanoarrays facilitate osteogenesis of BMSCs and stimulate the pro-healing M2 phenotype. However, adhesion, spreading, proliferation, and osteogenic differentiation of BMSCs are more pronounced on TiO₂-N N than both TiO₂-N and TiO₂-NW. TiO₂-NN also produces the best immune microenvironment, while TiO₂-NW is more favorable than TiO₂-NN from the viewpoint of cell adhesion and spreading of osteoblasts. © 2023

Original language	English
Pages (from-to)	233-244
Journal	Journal of Materials Science and Technology
Volume	150
Online published	10 Feb 2023
DOIs	https://doi.org/10.1016/j.jmst.2022.12.023
Publication status	Published - 1 Jul 2023

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 52171240), the Postdoctoral Science Foundation of China (No. 2021M691992), the Major Projects in Research and Development of Shanxi (Projects of International Cooperation, No. 201803D421090), the City University of Hong Kong Donation Research Grant (No. DON-RMG 9229021), the Hong Kong PDFS-RGC Postdoctoral Fellowship Scheme (Nos. PDFS2122-1S08 and CityU 9061014), and the Hong Kong HMRF (Health and Medical Research Fund) (Nos. 2120972 and CityU 9211320).

Research Keywords

Hydrothermal treatment
Immunomodulation
Osteogenic activity
TiO2 nanoarrays

RGC Funding Information

RGC-funded

Access Output

10.1016/j.jmst.2022.12.023

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{c3f737fd27f54e16ba1d6e0c8177ea91,

title = "Regulation of TiO2 nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation",

abstract = "The surface topography of implants plays a major role in osteogenesis and immunomodulation. In this study, three types of TiO2 nanoarrays including nanorod arrays with a diameter of 45 nm (TiO2-N), nanorod arrays with a diameter of 60 nm (TiO2-N N), and nanocone arrays (TiO2-NW) are prepared on titanium and the behavior of bone marrow stromal cells (BMSCs) and polarization of macrophages are studied. Compared to the planar titanium control, TiO2 nanoarrays facilitate osteogenesis of BMSCs and stimulate the pro-healing M2 phenotype. However, adhesion, spreading, proliferation, and osteogenic differentiation of BMSCs are more pronounced on TiO2-N N than both TiO2-N and TiO2-NW. TiO2-NN also produces the best immune microenvironment, while TiO2-NW is more favorable than TiO2-NN from the viewpoint of cell adhesion and spreading of osteoblasts. {\textcopyright} 2023",

keywords = "Hydrothermal treatment, Immunomodulation, Osteogenic activity, TiO2 nanoarrays",

author = "Ruoyu Li and Hongyu Zhang and Xiaohong Yao and Bin Tang and Chu, {Paul K} and Xiangyu Zhang",

year = "2023",

month = jul,

day = "1",

doi = "10.1016/j.jmst.2022.12.023",

language = "English",

volume = "150",

pages = "233--244",

journal = "Journal of Materials Science and Technology",

issn = "1005-0302",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Regulation of TiO2 nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation

AU - Li, Ruoyu

AU - Zhang, Hongyu

AU - Yao, Xiaohong

AU - Tang, Bin

AU - Chu, Paul K

AU - Zhang, Xiangyu

PY - 2023/7/1

Y1 - 2023/7/1

N2 - The surface topography of implants plays a major role in osteogenesis and immunomodulation. In this study, three types of TiO2 nanoarrays including nanorod arrays with a diameter of 45 nm (TiO2-N), nanorod arrays with a diameter of 60 nm (TiO2-N N), and nanocone arrays (TiO2-NW) are prepared on titanium and the behavior of bone marrow stromal cells (BMSCs) and polarization of macrophages are studied. Compared to the planar titanium control, TiO2 nanoarrays facilitate osteogenesis of BMSCs and stimulate the pro-healing M2 phenotype. However, adhesion, spreading, proliferation, and osteogenic differentiation of BMSCs are more pronounced on TiO2-N N than both TiO2-N and TiO2-NW. TiO2-NN also produces the best immune microenvironment, while TiO2-NW is more favorable than TiO2-NN from the viewpoint of cell adhesion and spreading of osteoblasts. © 2023

AB - The surface topography of implants plays a major role in osteogenesis and immunomodulation. In this study, three types of TiO2 nanoarrays including nanorod arrays with a diameter of 45 nm (TiO2-N), nanorod arrays with a diameter of 60 nm (TiO2-N N), and nanocone arrays (TiO2-NW) are prepared on titanium and the behavior of bone marrow stromal cells (BMSCs) and polarization of macrophages are studied. Compared to the planar titanium control, TiO2 nanoarrays facilitate osteogenesis of BMSCs and stimulate the pro-healing M2 phenotype. However, adhesion, spreading, proliferation, and osteogenic differentiation of BMSCs are more pronounced on TiO2-N N than both TiO2-N and TiO2-NW. TiO2-NN also produces the best immune microenvironment, while TiO2-NW is more favorable than TiO2-NN from the viewpoint of cell adhesion and spreading of osteoblasts. © 2023

KW - Hydrothermal treatment

KW - Immunomodulation

KW - Osteogenic activity

KW - TiO2 nanoarrays

UR - http://www.scopus.com/inward/record.url?scp=85148328986&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85148328986&origin=recordpage

U2 - 10.1016/j.jmst.2022.12.023

DO - 10.1016/j.jmst.2022.12.023

M3 - RGC 21 - Publication in refereed journal

SN - 1005-0302

VL - 150

SP - 233

EP - 244

JO - Journal of Materials Science and Technology

JF - Journal of Materials Science and Technology

ER -

Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation

Abstract

Funding

Research Keywords

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

DON_RMG: Fabrication, Characterization, and Properties of Functional Materials - RMGS

HMRF: Biocompatible Titanium Implants with Antibacterial Capability Arising from the Synergistic Effects of Mechanical and Electrical Interactions and Quantitative Bacteria Sensing Ability Based on Electron Transfer

Cite this