Regulation of TiO2 nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation

Ruoyu Li; Hongyu Zhang; Xiaohong Yao; Bin Tang; Paul K Chu; Xiangyu Zhang

doi:10.1016/j.jmst.2022.12.023

Author(s)

Ruoyu Li
Hongyu Zhang
Xiaohong Yao
Bin Tang
Xiangyu Zhang

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	233-244
Journal / Publication	Journal of Materials Science and Technology
Volume	150
Online published	10 Feb 2023
Publication status	Published - 1 Jul 2023

Link(s)

DOI	DOI https://doi.org/10.1016/j.jmst.2022.12.023 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85148328986&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(c3f737fd-27f5-4e16-ba1d-6e0c8177ea91).html

Abstract

The surface topography of implants plays a major role in osteogenesis and immunomodulation. In this study, three types of TiO₂ nanoarrays including nanorod arrays with a diameter of 45 nm (TiO₂-N), nanorod arrays with a diameter of 60 nm (TiO₂-N N), and nanocone arrays (TiO₂-NW) are prepared on titanium and the behavior of bone marrow stromal cells (BMSCs) and polarization of macrophages are studied. Compared to the planar titanium control, TiO₂ nanoarrays facilitate osteogenesis of BMSCs and stimulate the pro-healing M2 phenotype. However, adhesion, spreading, proliferation, and osteogenic differentiation of BMSCs are more pronounced on TiO₂-N N than both TiO₂-N and TiO₂-NW. TiO₂-NN also produces the best immune microenvironment, while TiO₂-NW is more favorable than TiO₂-NN from the viewpoint of cell adhesion and spreading of osteoblasts. © 2023

Research Area(s)

Hydrothermal treatment, Immunomodulation, Osteogenic activity, TiO2 nanoarrays

Citation Format(s)

[ RIS ] [ BibTeX ]

Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation. / Li, Ruoyu; Zhang, Hongyu; Yao, Xiaohong et al.
In: Journal of Materials Science and Technology, Vol. 150, 01.07.2023, p. 233-244.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Li, R, Zhang, H, Yao, X, Tang, B, Chu, PK & Zhang, X 2023, 'Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation', Journal of Materials Science and Technology, vol. 150, pp. 233-244. https://doi.org/10.1016/j.jmst.2022.12.023

Li, R., Zhang, H., Yao, X., Tang, B., Chu, P. K., & Zhang, X. (2023). Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation. Journal of Materials Science and Technology, 150, 233-244. https://doi.org/10.1016/j.jmst.2022.12.023

Li R, Zhang H, Yao X, Tang B, Chu PK, Zhang X. Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation. Journal of Materials Science and Technology. 2023 Jul 1;150:233-244. Epub 2023 Feb 10. doi: 10.1016/j.jmst.2022.12.023

Li, Ruoyu ; Zhang, Hongyu ; Yao, Xiaohong et al. / Regulation of TiO₂ nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation. In: Journal of Materials Science and Technology. 2023 ; Vol. 150. pp. 233-244.