Abstract
Impairment of the epithelial barrier function is closely linked to the pathogenesis of various gastrointestinal diseases, food allergies, type I diabetes, and other systematic diseases. Plant-derived polyphenols are natural secondary metabolites and exert various physiological benefits, including anti-inflammatory, anti-oxidative, anti-carcinogenic, and anti-aging effects. Recent studies also show the role of plant polyphenols in regulation of the intestinal barrier and prevention of intestinal inflammatory diseases. Here we summarize the regulatory pathways and mediators linking polyphenols to their beneficial effects on tight junction and gut epithelial barrier functions, and provide useful information about using polyphenols as nutraceuticals for intestinal diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 3830-3839 |
| Number of pages | 10 |
| Journal | Critical Reviews in Food Science and Nutrition |
| Volume | 57 |
| Issue number | 18 |
| Online published | 21 Sept 2017 |
| DOIs | |
| Publication status | Published - 2017 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Research Keywords
- Polyphenols
- intestinal epithelium
- barrier function
- tight junction
- signaling pathway
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