Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 295-307 |
Journal / Publication | Cell |
Volume | 137 |
Issue number | 2 |
Publication status | Published - 17 Apr 2009 |
Externally published | Yes |
Link(s)
Abstract
Planar cell polarity (PCP) is critical for morphogenesis in metazoans. PCP in vertebrates regulates stereocilia alignment in neurosensory cells of the cochlea and closure of the neural tube through convergence and extension movements (CE). Noncanonical Wnt morphogens regulate PCP and CE in vertebrates, but the molecular mechanisms remain unclear. Smurfs are ubiquitin ligases that regulate signaling, cell polarity and motility through spatiotemporally restricted ubiquitination of diverse substrates. Here, we report an unexpected role for Smurfs in controlling PCP and CE. Mice mutant for Smurf1 and Smurf2 display PCP defects in the cochlea and CE defects that include a failure to close the neural tube. Further, we show that Smurfs engage in a noncanonical Wnt signaling pathway that targets the core PCP protein Prickle1 for ubiquitin-mediated degradation. Our work thus uncovers ubiquitin ligases in a mechanistic link between noncanonical Wnt signaling and PCP/CE. © 2009 Elsevier Inc. All rights reserved.
Research Area(s)
- DEVBIO
Citation Format(s)
Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases. / Narimatsu, Masahiro; Bose, Rohit; Pye, Melanie; Zhang, Liang; Miller, Bryan; Ching, Peter; Sakuma, Rui; Luga, Valbona; Roncari, Luba; Attisano, Liliana; Wrana, Jeffrey L.
In: Cell, Vol. 137, No. 2, 17.04.2009, p. 295-307.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review