Regioselective and Direct Azidation of Anilines via Cu(II)-Catalyzed C-H Functionalization in Water

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Hongli Fang
  • Yandong Dou
  • Jingyan Ge
  • Mohit Chhabra
  • Pengfei Zhang
  • Yuguo Zheng
  • Qing Zhu

Detail(s)

Original languageEnglish
Pages (from-to)11212-11217
Journal / PublicationJournal of Organic Chemistry
Volume82
Issue number20
Online published19 Sep 2017
Publication statusPublished - 20 Oct 2017

Abstract

We report herein the first example of Cu(II)-catalyzed site selective azidation of aromatic amines via C-H functionalization in aqueous media. In our strategy, a mild reagent was utilized. H2O2 served as the oxidant, and sodium azide was used as the azidation reagent. This method could also be applied to late-stage functionalization of drugs that possess an aromatic amine moiety. In addition, we found that bromination or iodination on the ortho-position of aromatic amines could occur efficiently using this catalytic system.

Citation Format(s)

Regioselective and Direct Azidation of Anilines via Cu(II)-Catalyzed C-H Functionalization in Water. / Fang, Hongli; Dou, Yandong; Ge, Jingyan; Chhabra, Mohit; Sun, Hongyan; Zhang, Pengfei; Zheng, Yuguo; Zhu, Qing.

In: Journal of Organic Chemistry, Vol. 82, No. 20, 20.10.2017, p. 11212-11217.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal