TY - JOUR
T1 - Regioselective and Direct Azidation of Anilines via Cu(II)-Catalyzed C-H Functionalization in Water
AU - Fang, Hongli
AU - Dou, Yandong
AU - Ge, Jingyan
AU - Chhabra, Mohit
AU - Sun, Hongyan
AU - Zhang, Pengfei
AU - Zheng, Yuguo
AU - Zhu, Qing
PY - 2017/10/20
Y1 - 2017/10/20
N2 - We report herein the first example of Cu(II)-catalyzed site selective azidation of aromatic amines via C-H functionalization in aqueous media. In our strategy, a mild reagent was utilized. H2O2 served as the oxidant, and sodium azide was used as the azidation reagent. This method could also be applied to late-stage functionalization of drugs that possess an aromatic amine moiety. In addition, we found that bromination or iodination on the ortho-position of aromatic amines could occur efficiently using this catalytic system.
AB - We report herein the first example of Cu(II)-catalyzed site selective azidation of aromatic amines via C-H functionalization in aqueous media. In our strategy, a mild reagent was utilized. H2O2 served as the oxidant, and sodium azide was used as the azidation reagent. This method could also be applied to late-stage functionalization of drugs that possess an aromatic amine moiety. In addition, we found that bromination or iodination on the ortho-position of aromatic amines could occur efficiently using this catalytic system.
UR - http://www.scopus.com/inward/record.url?scp=85031919945&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85031919945&origin=recordpage
U2 - 10.1021/acs.joc.7b01594
DO - 10.1021/acs.joc.7b01594
M3 - RGC 21 - Publication in refereed journal
SN - 0022-3263
VL - 82
SP - 11212
EP - 11217
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 20
ER -