Redox-Active Organoruthenium(II)- and Organoosmium(II)-Copper(II) Complexes, with an Amidrazone-Morpholine Hybrid and [CuICl2]- as Counteranion and Their Antiproliferative Activity

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

8 Scopus Citations
View graph of relations

Author(s)

  • Kateryna Ohui
  • Denisa Darvasiova
  • Alexander Roller
  • Daniel Vegh
  • Peter Rapta
  • Grace Rui Shi Guan
  • Yi Hsuan Ou
  • Giorgia Pastorin
  • Vladimir B. Arion

Detail(s)

Original languageEnglish
Pages (from-to)2307-2318
Journal / PublicationOrganometallics
Volume38
Issue number10
Online published6 May 2019
Publication statusPublished - 28 May 2019
Externally publishedYes

Abstract

A novel proligand HLH has been prepared from 2-pyridinamidrazone and 6-(morpholinomethyl)pyridine-2-carboxaldehyde. Subsequently, starting from HLH and CuCl2·2H2O in the presence of triethylamine, a series of homo- and heterometallic complexes with [CuICl2]- as counteranion, namely mononuclear complex [CuIICl(HLOMe)][CuICl2] (1), dinuclear Ru(II)-Cu(II) complex [CuIIRuII(η6-p-cymene)Cl2(LH)][CuICl2]·1.5H2O (2·1.5H2O), Os(II)-Cu(II) complex [CuIIOsII(η6-p-cymene)Cl2(LH)][CuICl2]·H2O (3·H2O), and tetranuclear complex [CuII4(L1)2(L2)2Cl2]·5MeOH (4·5MeOH), where HLOMe, L1, and L2 are Schiff base ligands derived from HLH, were synthesized. The structures of metal complexes were established by X-ray diffraction. Complexes 1-3 demonstrated quasireversible one-electron reduction of Cu(II) in complex cations and one-electron oxidation of [CuICl2]- counterion, confirmed by UV-vis and EPR spectroelectrochemical measurements. They exhibited moderate antiproliferative activity against ovarian carcinoma and cervical adenocarcinoma cell lines in a micromolar concentration range, which was superior to the activity of HLH, CuCl2, and [CuICl2]-. The observed anticancer effects might be related to the ability of novel complexes to generate ROS, which was established by spin trapping experiments in cell-free media as well as by confocal microscopic imaging in ovarian carcinoma cells.

Citation Format(s)

Redox-Active Organoruthenium(II)- and Organoosmium(II)-Copper(II) Complexes, with an Amidrazone-Morpholine Hybrid and [CuICl2]- as Counteranion and Their Antiproliferative Activity. / Ohui, Kateryna; Babak, Maria V.; Darvasiova, Denisa et al.

In: Organometallics, Vol. 38, No. 10, 28.05.2019, p. 2307-2318.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review