Red-emitting rhodamine-based probe with large Stokes shift for ClO− detection

Qin Liang; Wenqiang Chen; Xiaojie Ren; Xiangzhi Song

doi:10.1016/j.tet.2022.133020

Red-emitting rhodamine-based probe with large Stokes shift for ClO⁻ detection

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Overview

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Author(s)

Qin Liang
Wenqiang Chen
Xiaojie Ren
Xiangzhi Song

Related Research Unit(s)

Detail(s)

Original language	English
Article number	133020
Journal / Publication	Tetrahedron
Volume	127
Online published	7 Sep 2022
Publication status	Published - 19 Nov 2022

Link(s)

DOI	DOI https://doi.org/10.1016/j.tet.2022.133020 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85140289659&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(a5d08fa5-68ed-451b-82fc-39ef8f46d37e).html

Abstract

A fluorescent rhodamine dye, HN, was prepared by introducing tetrahydroquinoxalinyl donor, which displayed far-red emission (687 nm), large Stokes shift (84 nm), and relatively high fluorescent quantum yield (0.33). Based on HN dye, a fluorescent probe, HN-HClO, was developed for hypochlorite (ClO⁻) detection. The probe HN-HClO exhibited fast response time (within 100 s), excellent sensitivity (LOD = 74 nM), and good selectivity toward ClO⁻. The probe HN-HClO was capable of imaging ClO⁻ in both living cells and zebrafish. It could also monitor the endogenously generated ClO⁻ in the MPO-catalyzed system.