Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy

Lulu Yue (Co-first Author), Yilin Liu (Co-first Author), Jing Wang, Yihan Wu, Jinliang Liu, Zhen Zhang*, Yong Zhang*, Xiaohui Zhu*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

1 Citation (Scopus)

Abstract

Afterglow luminescence has attracted increasing attention due to its prolonged emission, reduced autofluorescence, and minimized photodamage. However, persistent luminescence typically requires high-energy excitation (e.g., ultraviolet and visible light), which has limited tissue penetration. Herein, we have developed a one-pot surface segregation strategy to construct NIR-excitable afterglow superclusters (UCZG-SCs) by modularly assembling spinel-phase afterglow nanoparticles (Zn1.1Ga1.8Ge0.1O4:Cr3+) and hexagonal-phase upconversion nanoparticles (NaYF4:Yb,Tm@NaLuF4:Y). Since the proposed methodology does not require crystal lattice similarity, it enables fabrication of various NIR-excitable persistent superclusters with great flexibility in size, composition, and luminescent profiles. As a proof of concept, an injectable persistent implant is established by embedding UCZG-SCs in the oleosol of poly(lactic-co-glycolic acid)/N-methylpyrrolidone, which serves as an inner-body lamp to excite photosensitizers for photodynamic therapy. With its excellent charging-recharging stability, a repetitive phototherapy under periodic 980 nm light illumination is accomplished, which significantly improves phototherapeutic efficiency and restrains tumor growth. © 2024 American Chemical Society.
Original languageEnglish
Pages (from-to)15406–15413
JournalNano Letters
Volume24
Issue number48
Online published21 Nov 2024
DOIs
Publication statusPublished - 4 Dec 2024

Research Keywords

  • NIR
  • Persistent luminescence
  • photodynamic therapy
  • supercluster
  • upconversion

Publisher's Copyright Statement

  • COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.4c04719.

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