Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy

Lulu Yue; Yilin Liu; Jing Wang; Yihan Wu; Jinliang Liu; Zhen Zhang; Yong Zhang; Xiaohui Zhu

doi:10.1021/acs.nanolett.4c04719

Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy

Lulu Yue (Co-first Author), Yilin Liu (Co-first Author), Jing Wang, Yihan Wu, Jinliang Liu, Zhen Zhang^*, Yong Zhang^*, Xiaohui Zhu^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

1 Citation (Scopus)

Abstract

Afterglow luminescence has attracted increasing attention due to its prolonged emission, reduced autofluorescence, and minimized photodamage. However, persistent luminescence typically requires high-energy excitation (e.g., ultraviolet and visible light), which has limited tissue penetration. Herein, we have developed a one-pot surface segregation strategy to construct NIR-excitable afterglow superclusters (UCZG-SCs) by modularly assembling spinel-phase afterglow nanoparticles (Zn_1.1Ga_1.8Ge_0.1O₄:Cr³⁺) and hexagonal-phase upconversion nanoparticles (NaYF₄:Yb,Tm@NaLuF₄:Y). Since the proposed methodology does not require crystal lattice similarity, it enables fabrication of various NIR-excitable persistent superclusters with great flexibility in size, composition, and luminescent profiles. As a proof of concept, an injectable persistent implant is established by embedding UCZG-SCs in the oleosol of poly(lactic-co-glycolic acid)/N-methylpyrrolidone, which serves as an inner-body lamp to excite photosensitizers for photodynamic therapy. With its excellent charging-recharging stability, a repetitive phototherapy under periodic 980 nm light illumination is accomplished, which significantly improves phototherapeutic efficiency and restrains tumor growth. © 2024 American Chemical Society.

Original language	English
Pages (from-to)	15406–15413
Journal	Nano Letters
Volume	24
Issue number	48
Online published	21 Nov 2024
DOIs	https://doi.org/10.1021/acs.nanolett.4c04719
Publication status	Published - 4 Dec 2024

Research Keywords

NIR
Persistent luminescence
photodynamic therapy
supercluster
upconversion

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COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.4c04719.

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title = "Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy",

abstract = "Afterglow luminescence has attracted increasing attention due to its prolonged emission, reduced autofluorescence, and minimized photodamage. However, persistent luminescence typically requires high-energy excitation (e.g., ultraviolet and visible light), which has limited tissue penetration. Herein, we have developed a one-pot surface segregation strategy to construct NIR-excitable afterglow superclusters (UCZG-SCs) by modularly assembling spinel-phase afterglow nanoparticles (Zn1.1Ga1.8Ge0.1O4:Cr3+) and hexagonal-phase upconversion nanoparticles (NaYF4:Yb,Tm@NaLuF4:Y). Since the proposed methodology does not require crystal lattice similarity, it enables fabrication of various NIR-excitable persistent superclusters with great flexibility in size, composition, and luminescent profiles. As a proof of concept, an injectable persistent implant is established by embedding UCZG-SCs in the oleosol of poly(lactic-co-glycolic acid)/N-methylpyrrolidone, which serves as an inner-body lamp to excite photosensitizers for photodynamic therapy. With its excellent charging-recharging stability, a repetitive phototherapy under periodic 980 nm light illumination is accomplished, which significantly improves phototherapeutic efficiency and restrains tumor growth. {\textcopyright} 2024 American Chemical Society.",

keywords = "NIR, Persistent luminescence, photodynamic therapy, supercluster, upconversion",

author = "Lulu Yue and Yilin Liu and Jing Wang and Yihan Wu and Jinliang Liu and Zhen Zhang and Yong Zhang and Xiaohui Zhu",

year = "2024",

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doi = "10.1021/acs.nanolett.4c04719",

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TY - JOUR

T1 - Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy

AU - Yue, Lulu

AU - Liu, Yilin

AU - Wang, Jing

AU - Wu, Yihan

AU - Liu, Jinliang

AU - Zhang, Zhen

AU - Zhang, Yong

AU - Zhu, Xiaohui

PY - 2024/12/4

Y1 - 2024/12/4

N2 - Afterglow luminescence has attracted increasing attention due to its prolonged emission, reduced autofluorescence, and minimized photodamage. However, persistent luminescence typically requires high-energy excitation (e.g., ultraviolet and visible light), which has limited tissue penetration. Herein, we have developed a one-pot surface segregation strategy to construct NIR-excitable afterglow superclusters (UCZG-SCs) by modularly assembling spinel-phase afterglow nanoparticles (Zn1.1Ga1.8Ge0.1O4:Cr3+) and hexagonal-phase upconversion nanoparticles (NaYF4:Yb,Tm@NaLuF4:Y). Since the proposed methodology does not require crystal lattice similarity, it enables fabrication of various NIR-excitable persistent superclusters with great flexibility in size, composition, and luminescent profiles. As a proof of concept, an injectable persistent implant is established by embedding UCZG-SCs in the oleosol of poly(lactic-co-glycolic acid)/N-methylpyrrolidone, which serves as an inner-body lamp to excite photosensitizers for photodynamic therapy. With its excellent charging-recharging stability, a repetitive phototherapy under periodic 980 nm light illumination is accomplished, which significantly improves phototherapeutic efficiency and restrains tumor growth. © 2024 American Chemical Society.

AB - Afterglow luminescence has attracted increasing attention due to its prolonged emission, reduced autofluorescence, and minimized photodamage. However, persistent luminescence typically requires high-energy excitation (e.g., ultraviolet and visible light), which has limited tissue penetration. Herein, we have developed a one-pot surface segregation strategy to construct NIR-excitable afterglow superclusters (UCZG-SCs) by modularly assembling spinel-phase afterglow nanoparticles (Zn1.1Ga1.8Ge0.1O4:Cr3+) and hexagonal-phase upconversion nanoparticles (NaYF4:Yb,Tm@NaLuF4:Y). Since the proposed methodology does not require crystal lattice similarity, it enables fabrication of various NIR-excitable persistent superclusters with great flexibility in size, composition, and luminescent profiles. As a proof of concept, an injectable persistent implant is established by embedding UCZG-SCs in the oleosol of poly(lactic-co-glycolic acid)/N-methylpyrrolidone, which serves as an inner-body lamp to excite photosensitizers for photodynamic therapy. With its excellent charging-recharging stability, a repetitive phototherapy under periodic 980 nm light illumination is accomplished, which significantly improves phototherapeutic efficiency and restrains tumor growth. © 2024 American Chemical Society.

KW - NIR

KW - Persistent luminescence

KW - photodynamic therapy

KW - supercluster

KW - upconversion

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U2 - 10.1021/acs.nanolett.4c04719

DO - 10.1021/acs.nanolett.4c04719

M3 - RGC 21 - Publication in refereed journal

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EP - 15413

JO - Nano Letters

JF - Nano Letters

IS - 48

ER -

Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy

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Research Keywords

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