Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Zepeng Xu
  • Pu Han
  • Xiaomei Li
  • Qi Peng
  • Chao Su
  • Baihan Huang
  • Dedong Li
  • Rong Zhang
  • Mingxiong Tian
  • Lutang Fu
  • Yuanzhu Gao
  • Xin Zhao
  • Kefang Liu
  • Jianxun Qi
  • George F. Gao
  • Peiyi Wang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)630-640, e1-e10
Journal / PublicationCell
Volume185
Issue number4
Online published6 Jan 2022
Publication statusPublished - 17 Feb 2022

Abstract

The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protein, has risen to intense scientific and public attention. Here, we studied the binding properties between the human receptor ACE2 (hACE2) and the VOC RBDs and resolved the crystal and cryoelectron microscopy structures of the omicron RBD-hACE2 complex as well as the crystal structure of the delta RBD-hACE2 complex. We found that, unlike alpha, beta, and gamma, omicron RBD binds to hACE2 at a similar affinity to that of the prototype RBD, which might be due to compensation of multiple mutations for both immune escape and transmissibility. The complex structures of omicron RBD-hACE2 and delta RBD-hACE2 reveal the structural basis of how RBD-specific mutations bind to hACE2.

Research Area(s)

  • delta, hACE2, omicron, RBD, receptor-binding domain, structure, variants of concern, VOCs

Citation Format(s)

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2. / Han, Pengcheng; Li, Linjie; Liu, Sheng et al.
In: Cell, Vol. 185, No. 4, 17.02.2022, p. 630-640, e1-e10.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review