Recent progress in stimuli-responsive DNA-based logic gates: Design, working principles and biological applications

Ling Sum Liu; Hoi Man Leung; Yuzhen Cai; Pik Kwan Lo

doi:10.1002/smo.20230023

Recent progress in stimuli-responsive DNA-based logic gates: Design, working principles and biological applications

Ling Sum Liu
, Hoi Man Leung
, Yuzhen Cai
, Pik Kwan Lo^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

43 Downloads (CityUHK Scholars)

Abstract

Stimuli-responsive DNA-based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology. These gates exploit the unique properties of DNA molecules to perform programmable computational operations in response to specific stimuli. This review provides a comprehensive overview of recent advancements in the design, working principles, and applications of stimuli-responsive DNA-based logic gates. The progress made in developing various types of logic gates triggered by metal ions, pH, oligonucleotides, small molecules, proteins, and light is highlighted. The applications of these logic gates in imaging and biosensing, drug delivery, synthetic biology and molecular computing are discussed. This review underscores the significant contributions and future prospects of stimuli-responsive DNA-based logic gates in advancing the field of nanotechnology.

© 2024 The Authors. Smart Molecules published by John Wiley & Sons Australia, Ltd on behalf of Dalian University of Technology.

Original language	English
Article number	e20230023
Number of pages	19
Journal	Smart Molecules
Volume	2
Issue number	1
Online published	14 Feb 2024
DOIs	https://doi.org/10.1002/smo.20230023
Publication status	Published - Mar 2024

Funding

This work is supported by Hong Kong Research Grants Council (11307421, 11301220, and 11304719), Health and Medical Research Fund (09203576 and 07181396), National Science Foundation of China (21574109 and 217780430), The Science and Technology Innovation Committee of Shenzhen Municipality (JCYJ20190812160203619), City University of Hong Kong 7005832 and 7006006.

Research Keywords

DNA logic gates
drug delivery
imaging
molecular computation
stimuli-responsive

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

RGC Funding Information

RGC-funded

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10.1002/smo.20230023

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1 Active
4 Finished

HMRF: Development of Light-responsive Nanocarriers as Controlled Drug Release Platform for Triple-negative Breast Cancer Therapy
LO, P. K. P. (Principal Investigator / Project Coordinator) & CHIN, R. Y. M. (Co-Investigator)
1/08/22 → …
Project: Research
GRF: Design, Synthesis and Characterization of Multi-Functionalized Two-Photon Caging Platforms and their Application to Neurotransmitter Photorelease
LO, P. K. P. (Principal Investigator / Project Coordinator) & TIN, C. (Co-Investigator)
1/01/22 → 3/06/26
Project: Research
GRF: Design, Synthesis and Applications of Two-Photon Photoactivatable Nucleic Acids in DNA Nanotechnology
LO, P. K. P. (Principal Investigator / Project Coordinator)
1/01/21 → 5/06/25
Project: Research

Cite this

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title = "Recent progress in stimuli-responsive DNA-based logic gates: Design, working principles and biological applications",

abstract = "Stimuli-responsive DNA-based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology. These gates exploit the unique properties of DNA molecules to perform programmable computational operations in response to specific stimuli. This review provides a comprehensive overview of recent advancements in the design, working principles, and applications of stimuli-responsive DNA-based logic gates. The progress made in developing various types of logic gates triggered by metal ions, pH, oligonucleotides, small molecules, proteins, and light is highlighted. The applications of these logic gates in imaging and biosensing, drug delivery, synthetic biology and molecular computing are discussed. This review underscores the significant contributions and future prospects of stimuli-responsive DNA-based logic gates in advancing the field of nanotechnology. {\textcopyright} 2024 The Authors. Smart Molecules published by John Wiley \& Sons Australia, Ltd on behalf of Dalian University of Technology.",

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T2 - Design, working principles and biological applications

AU - Liu, Ling Sum

AU - Leung, Hoi Man

AU - Cai, Yuzhen

AU - Lo, Pik Kwan

PY - 2024/3

Y1 - 2024/3

N2 - Stimuli-responsive DNA-based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology. These gates exploit the unique properties of DNA molecules to perform programmable computational operations in response to specific stimuli. This review provides a comprehensive overview of recent advancements in the design, working principles, and applications of stimuli-responsive DNA-based logic gates. The progress made in developing various types of logic gates triggered by metal ions, pH, oligonucleotides, small molecules, proteins, and light is highlighted. The applications of these logic gates in imaging and biosensing, drug delivery, synthetic biology and molecular computing are discussed. This review underscores the significant contributions and future prospects of stimuli-responsive DNA-based logic gates in advancing the field of nanotechnology. © 2024 The Authors. Smart Molecules published by John Wiley & Sons Australia, Ltd on behalf of Dalian University of Technology.

AB - Stimuli-responsive DNA-based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology. These gates exploit the unique properties of DNA molecules to perform programmable computational operations in response to specific stimuli. This review provides a comprehensive overview of recent advancements in the design, working principles, and applications of stimuli-responsive DNA-based logic gates. The progress made in developing various types of logic gates triggered by metal ions, pH, oligonucleotides, small molecules, proteins, and light is highlighted. The applications of these logic gates in imaging and biosensing, drug delivery, synthetic biology and molecular computing are discussed. This review underscores the significant contributions and future prospects of stimuli-responsive DNA-based logic gates in advancing the field of nanotechnology. © 2024 The Authors. Smart Molecules published by John Wiley & Sons Australia, Ltd on behalf of Dalian University of Technology.

KW - DNA logic gates

KW - drug delivery

KW - imaging

KW - molecular computation

KW - stimuli-responsive

U2 - 10.1002/smo.20230023

DO - 10.1002/smo.20230023

M3 - RGC 21 - Publication in refereed journal

C2 - 40625523

VL - 2

JO - Smart Molecules

JF - Smart Molecules

IS - 1

M1 - e20230023

ER -

Recent progress in stimuli-responsive DNA-based logic gates: Design, working principles and biological applications

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

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Projects

HMRF: Development of Light-responsive Nanocarriers as Controlled Drug Release Platform for Triple-negative Breast Cancer Therapy

GRF: Design, Synthesis and Characterization of Multi-Functionalized Two-Photon Caging Platforms and their Application to Neurotransmitter Photorelease

GRF: Design, Synthesis and Applications of Two-Photon Photoactivatable Nucleic Acids in DNA Nanotechnology

Cite this