Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications

Lawrence Cho-Cheung Lee; Lili Huang; Peter Kam-Keung Leung; Kenneth Kam-Wing Lo

doi:10.1002/ejic.202200455

Author(s)

Lawrence Cho-Cheung Lee (Co-first Author)
Lili Huang (Co-first Author)
Peter Kam-Keung Leung
Kenneth Kam-Wing Lo

Related Research Unit(s)

Detail(s)

Original language	English
Article number	e202200455
Journal / Publication	European Journal of Inorganic Chemistry
Volume	2022
Issue number	35
Online published	29 Sept 2022
Publication status	Published - 16 Dec 2022

Link(s)

DOI	DOI https://doi.org/10.1002/ejic.202200455 Final Published version
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Attachment(s)	Documents 122934671.pdf Post-print, 1.96 MB, PDF Publisher's Copyright Statement COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the peer reviewed version of the following article: Lee, L. C-C., Huang, L., Leung, P. K-K., & Lo, K. K-W. (2022). Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications. European Journal of Inorganic Chemistry, 2022(35), [e202200455], which has been published in final form at https://doi.org/10.1002/ejic.202200455. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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Abstract

Peptides are attractive for diagnostic and therapeutic applications due to their small molecular size, ease of synthesis and chemical modifications, high target affinity and specificity, efficient tissue penetration, and low immunogenicity. In the past decade, there has been enormous interest in the utilization of photofunctional transition metal complexes as cellular probes, bioimaging reagents, and therapeutic agents. The interest stems from the intriguing photophysical and photochemical properties of the complexes, including large Stokes’ shifts, long emission lifetimes, high photostability, and high singlet oxygen-photosensitization efficiency. In this Review, we summarize recent advances in the development of photofunctional transition metal−peptide conjugates for bioimaging and therapeutic applications, with a focus on the cellular uptake, intracellular localization, and (photo)cytotoxic activity of the conjugates. Our perspective on the current challenges and future development of photofunctional transition metal−peptide conjugates as diagnostic and therapeutic tools is also provided.