Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications

Lawrence Cho-Cheung Lee; Lili Huang; Peter Kam-Keung Leung; Kenneth Kam-Wing Lo

doi:10.1002/ejic.202200455

Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications

Lawrence Cho-Cheung Lee (Co-first Author)
, Lili Huang (Co-first Author)
, Peter Kam-Keung Leung
, Kenneth Kam-Wing Lo^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

9 Citations (Scopus)

76 Downloads (CityUHK Scholars)

Abstract

Peptides are attractive for diagnostic and therapeutic applications due to their small molecular size, ease of synthesis and chemical modifications, high target affinity and specificity, efficient tissue penetration, and low immunogenicity. In the past decade, there has been enormous interest in the utilization of photofunctional transition metal complexes as cellular probes, bioimaging reagents, and therapeutic agents. The interest stems from the intriguing photophysical and photochemical properties of the complexes, including large Stokes’ shifts, long emission lifetimes, high photostability, and high singlet oxygen-photosensitization efficiency. In this Review, we summarize recent advances in the development of photofunctional transition metal−peptide conjugates for bioimaging and therapeutic applications, with a focus on the cellular uptake, intracellular localization, and (photo)cytotoxic activity of the conjugates. Our perspective on the current challenges and future development of photofunctional transition metal−peptide conjugates as diagnostic and therapeutic tools is also provided.

Original language	English
Article number	e202200455
Journal	European Journal of Inorganic Chemistry
Volume	2022
Issue number	35
Online published	29 Sept 2022
DOIs	https://doi.org/10.1002/ejic.202200455
Publication status	Published - 16 Dec 2022

Funding

We thank the Hong Kong Research Grants Council (Project No. CityU 11300019, CityU 11302820, CityU 11301121, T42-103/16- N, C6014-20W, C7075-21GF, and N_CityU104/21) for financial support. We also acknowledge the funding support from “Laboratory for Synthetic Chemistry and Chemical Biology” under the Health@InnoHK Program launched by Innovation and Technology Commission, The Government of Hong Kong SAR, P. R. China. L.H. acknowledges the receipt of a Postgraduate Studentship administrated by City University of Hong Kong.

Research Keywords

Bioconjugation
Cytotoxicity
Imaging agents
Luminescence
Peptides
Therapeutic agents
Transition metal complexes

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the peer reviewed version of the following article: Lee, L. C-C., Huang, L., Leung, P. K-K., & Lo, K. K-W. (2022). Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications. European Journal of Inorganic Chemistry, 2022(35), [e202200455], which has been published in final form at https://doi.org/10.1002/ejic.202200455.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

RGC Funding Information

RGC-funded

Access Output

10.1002/ejic.202200455

122934671.pdfPost-print, 1.96 MB

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{b3bb96f64c5e4fbc813812c903314fbe,

title = "Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications",

abstract = "Peptides are attractive for diagnostic and therapeutic applications due to their small molecular size, ease of synthesis and chemical modifications, high target affinity and specificity, efficient tissue penetration, and low immunogenicity. In the past decade, there has been enormous interest in the utilization of photofunctional transition metal complexes as cellular probes, bioimaging reagents, and therapeutic agents. The interest stems from the intriguing photophysical and photochemical properties of the complexes, including large Stokes{\textquoteright} shifts, long emission lifetimes, high photostability, and high singlet oxygen-photosensitization efficiency. In this Review, we summarize recent advances in the development of photofunctional transition metal−peptide conjugates for bioimaging and therapeutic applications, with a focus on the cellular uptake, intracellular localization, and (photo)cytotoxic activity of the conjugates. Our perspective on the current challenges and future development of photofunctional transition metal−peptide conjugates as diagnostic and therapeutic tools is also provided.",

keywords = "Bioconjugation, Cytotoxicity, Imaging agents, Luminescence, Peptides, Therapeutic agents, Transition metal complexes",

author = "Lee, \{Lawrence Cho-Cheung\} and Lili Huang and Leung, \{Peter Kam-Keung\} and Lo, \{Kenneth Kam-Wing\}",

year = "2022",

month = dec,

day = "16",

doi = "10.1002/ejic.202200455",

language = "English",

volume = "2022",

journal = "European Journal of Inorganic Chemistry",

issn = "1434-1948",

publisher = "Wiley-VCH Verlag GmbH",

number = "35",

}

Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications. / Lee, Lawrence Cho-Cheung (Co-first Author); Huang, Lili (Co-first Author); Leung, Peter Kam-Keung et al.
In: European Journal of Inorganic Chemistry, Vol. 2022, No. 35, e202200455, 16.12.2022.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications

AU - Lee, Lawrence Cho-Cheung

AU - Huang, Lili

AU - Leung, Peter Kam-Keung

AU - Lo, Kenneth Kam-Wing

PY - 2022/12/16

Y1 - 2022/12/16

N2 - Peptides are attractive for diagnostic and therapeutic applications due to their small molecular size, ease of synthesis and chemical modifications, high target affinity and specificity, efficient tissue penetration, and low immunogenicity. In the past decade, there has been enormous interest in the utilization of photofunctional transition metal complexes as cellular probes, bioimaging reagents, and therapeutic agents. The interest stems from the intriguing photophysical and photochemical properties of the complexes, including large Stokes’ shifts, long emission lifetimes, high photostability, and high singlet oxygen-photosensitization efficiency. In this Review, we summarize recent advances in the development of photofunctional transition metal−peptide conjugates for bioimaging and therapeutic applications, with a focus on the cellular uptake, intracellular localization, and (photo)cytotoxic activity of the conjugates. Our perspective on the current challenges and future development of photofunctional transition metal−peptide conjugates as diagnostic and therapeutic tools is also provided.

AB - Peptides are attractive for diagnostic and therapeutic applications due to their small molecular size, ease of synthesis and chemical modifications, high target affinity and specificity, efficient tissue penetration, and low immunogenicity. In the past decade, there has been enormous interest in the utilization of photofunctional transition metal complexes as cellular probes, bioimaging reagents, and therapeutic agents. The interest stems from the intriguing photophysical and photochemical properties of the complexes, including large Stokes’ shifts, long emission lifetimes, high photostability, and high singlet oxygen-photosensitization efficiency. In this Review, we summarize recent advances in the development of photofunctional transition metal−peptide conjugates for bioimaging and therapeutic applications, with a focus on the cellular uptake, intracellular localization, and (photo)cytotoxic activity of the conjugates. Our perspective on the current challenges and future development of photofunctional transition metal−peptide conjugates as diagnostic and therapeutic tools is also provided.

KW - Bioconjugation

KW - Cytotoxicity

KW - Imaging agents

KW - Luminescence

KW - Peptides

KW - Therapeutic agents

KW - Transition metal complexes

UR - https://www.scopus.com/pages/publications/85141176926#tab=impact

UR - https://www.scopus.com/pages/publications/85141176926

U2 - 10.1002/ejic.202200455

DO - 10.1002/ejic.202200455

M3 - RGC 21 - Publication in refereed journal

SN - 1434-1948

VL - 2022

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 35

M1 - e202200455

ER -

Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

NSFC: Design and Preparation of Phosphorescent Lifetime-Responsive Polymeric Probes for Enzyme Targeting and Catalytic Activity Sensing in Living Cells

GRF: Modulation of the Luminescence Properties and Photocytotoxic Activity of Transition Metal Complexes through Dissociative Bioorthogonal Reactions for Diagnostic and Therapeutic Applications

CRF-ExtU-Lead: New Aggregation-Induced Emission Systems: Solving the Existing Problems in Bioimaging and Developing New Biological Applications

Cite this

Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

NSFC: Design and Preparation of Phosphorescent Lifetime-Responsive Polymeric Probes for Enzyme Targeting and Catalytic Activity Sensing in Living Cells

GRF: Modulation of the Luminescence Properties and Photocytotoxic Activity of Transition Metal Complexes through Dissociative Bioorthogonal Reactions for Diagnostic and Therapeutic Applications

CRF-ExtU-Lead: New Aggregation-Induced Emission Systems: Solving the Existing Problems in Bioimaging and Developing New Biological Applications

Cite this