Recent development of luminescent rhenium(I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Pages (from-to)16357-16380
Journal / PublicationDalton Transactions
Volume46
Issue number47
Online published18 Oct 2017
Publication statusPublished - 21 Dec 2017

Abstract

There has been fast-growing interest in the exploitation of the photophysical and photochemical properties of luminescent transition metal complexes in biological applications, with a focus on both diagnostic and therapeutic aspects. In particular, the design of luminescent rhenium(i) tricarbonyl polypyridine complexes as cellular imaging reagents and anticancer drugs has received considerable attention for a number of reasons. First, most rhenium(i) tricarbonyl polypyridine complexes possess diverse photophysical and photochemical properties through the coordination of functionalized ligands. The typical photophysical properties of the complexes such as large Stokes shifts, long emission lifetimes, and high photostability allow them to serve as attractive candidates for optical imaging. Also, the cellular uptake of the complexes can be readily quantified by atomic absorption spectroscopy and inductively coupled plasma-mass spectrometry. Additionally, owing to the characteristic infrared absorption bands and the isostructural relationship between rhenium and technetium-99m, rhenium(i) tricarbonyl complexes have been exploited as multimodal imaging reagents for vibrational and radio-imaging, respectively. Furthermore, the facile photosensitizing properties and the three carbon monoxide (CO) ligands render rhenium(i) tricarbonyl complexes promising candidates as photodynamic therapy reagents and photoactivatable CO-releasing molecules, respectively, for cancer treatment. In this Perspective, we describe the recent development of luminescent rhenium(i) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents.

Citation Format(s)

Recent development of luminescent rhenium(I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents. / Lee, Lawrence Cho-Cheung; Leung, Kam-Keung; Lo, Kenneth Kam-Wing.

In: Dalton Transactions, Vol. 46, No. 47, 21.12.2017, p. 16357-16380.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review