Recent advances of microneedles used towards stimuli-responsive drug delivery, disease theranostics, and bioinspired applications

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jingbo Yang
  • Haoxiang Zhang
  • Lelun Jiang
  • Yu Shrike Zhang
  • Maobin Xie

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number130561
Journal / PublicationChemical Engineering Journal
Volume426
Online published17 Jun 2021
Publication statusOnline published - 17 Jun 2021

Abstract

Microneedles (MNs) as a minimally invasive tool have drawn increasing attention recently. They possess many prominent advantages, including pain-free, self-administration, and ease-of-disposal, when compared to the traditional administration tools. This review summarizes the latest developments of the MN technology and focuses on the advanced applications in stimuli-responsive drug delivery, disease theranostics, and bioinspired functions. Starting from a brief overview of different types of MNs based on their structures and materials, we then detail the fabrication strategies, including hot embossing, micro-molding, thermal-drawing lithography, magnetorheological lithography, laser-drilling, and the emerging 3D printing techniques. Later, the recent biomedical applications of these MNs are highlighted, including stimuli-responsive drug release for disease therapy, biosensing for disease diagnosis, and bioinspired applications.

Research Area(s)

  • Microneedles, 3D printing, Stimuli-responsive, Drug delivery, Disease theranostics, Bioinspired applications

Citation Format(s)

Recent advances of microneedles used towards stimuli-responsive drug delivery, disease theranostics, and bioinspired applications. / Yang, Jingbo; Zhang, Haoxiang; Hu, Tianli; Xu, Chenjie; Jiang, Lelun; Zhang, Yu Shrike; Xie, Maobin.

In: Chemical Engineering Journal, Vol. 426, 130561, 15.12.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review