Recent advances in RNA structurome

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

15 Scopus Citations
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  • Bingbing Xu
  • Yanda Zhu
  • Changchang Cao
  • Hao Chen
  • Qiongli Jin
  • Guangnan Li
  • Junfeng Ma
  • Siwy Ling Yang
  • Jianghui Zhu
  • Yiliang Ding
  • Xianyang Fang
  • Yongfeng Jin
  • Aiming Ren
  • Yue Wan
  • Zhiye Wang
  • Yuanchao Xue
  • Huakun Zhang
  • Qiangfeng Cliff Zhang
  • Yu Zhou


Original languageEnglish
Pages (from-to)1285–1324
Journal / PublicationScience China Life Sciences
Issue number7
Online published14 Jun 2022
Publication statusPublished - Jul 2022


RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers - including RNA processing, transport, localization, and mRNA translation - across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes (e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications.

Research Area(s)

  • RNA structurome, high-throughput techniques, genome-wide, 3D structure, RNA secondary structure, SARS-CoV-2, decoding, function

Citation Format(s)

Recent advances in RNA structurome. / Xu, Bingbing; Zhu, Yanda; Cao, Changchang et al.
In: Science China Life Sciences, Vol. 65, No. 7, 07.2022, p. 1285–1324.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review