Recent Advances in Managing Atherosclerosis via Nanomedicine

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Cecilia Ka Wing Chan
  • Lei Zhang
  • Chak Kwong Cheng
  • Hongrong Yang
  • Xiao Yu Tian
  • Chung Hang Jonathan Choi

Detail(s)

Original languageEnglish
Article number1702793
Journal / PublicationSmall
Volume14
Issue number4
Publication statusPublished - 25 Jan 2018
Externally publishedYes

Abstract

Atherosclerosis, driven by chronic inflammation of the arteries and lipid accumulation on the blood vessel wall, underpins many cardiovascular diseases with high mortality rates globally, such as stroke and ischemic heart disease. Engineered bio-nanomaterials are now under active investigation as carriers of therapeutic and/or imaging agents to atherosclerotic plaques. This Review summarizes the latest bio-nanomaterial-based strategies for managing atherosclerosis published over the past five years, a period marked by a rapid surge in preclinical applications of bio-nanomaterials for imaging and/or treating atherosclerosis. To start, the biomarkers exploited by emerging bio-nanomaterials for targeting various components of atherosclerotic plaques are outlined. In addition, recent efforts to rationally design and screen for bio-nanomaterials with the optimal physicochemical properties for targeting plaques are presented. Moreover, the latest preclinical applications of bio-nanomaterials as carriers of imaging, therapeutic, or theranostic agents to atherosclerotic plaques are discussed. Finally, a mechanistic understanding of the interactions between bio-nanomaterials and the plaque (“athero–nano” interactions) is suggested, the opportunities and challenges in the clinical translation of bio-nanomaterials for managing atherosclerosis are discussed, and recent clinical trials for atherosclerotic nanomedicines are introduced.

Research Area(s)

  • atherosclerosis, bio-nanomaterials, imaging, nanomedicine, therapeutics

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Recent Advances in Managing Atherosclerosis via Nanomedicine. / Chan, Cecilia Ka Wing; Zhang, Lei; Cheng, Chak Kwong; Yang, Hongrong; Huang, Yu; Tian, Xiao Yu; Choi, Chung Hang Jonathan.

In: Small, Vol. 14, No. 4, 1702793, 25.01.2018.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review