Recent advances in cellular optogenetics for photomedicine

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

8 Scopus Citations
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Author(s)

  • Bing Chen
  • Meihui Cui
  • Hanjie Wang

Detail(s)

Original languageEnglish
Article number114457
Journal / PublicationAdvanced Drug Delivery Reviews
Volume188
Online published16 Jul 2022
Publication statusPublished - Sept 2022

Link(s)

Abstract

Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulating neural circuits. In an optogenetic system, optical stimulation can be precisely delivered to brain tissue to achieve regulation of cellular electrical activity with unprecedented spatio-temporal resolution in living organisms. In recent years, the development of various optical actuators and novel light-delivery techniques has greatly expanded the scope of optogenetics, enabling the control of other signal pathways in non-neuronal cells for different biomedical applications, such as phototherapy and immunotherapy. This review focuses on the recent advances in optogenetic regulation of cellular activities for photomedicine. We discuss emerging optogenetic tools and light-delivery platforms, along with a survey of optogenetic execution in mammalian and microbial cells.

Research Area(s)

  • Light delivery, Neuronal regulation, Optogenetic tools, Phototherapy, Signaling pathways

Citation Format(s)

Recent advances in cellular optogenetics for photomedicine. / Chen, Bing; Cui, Meihui; Wang, Yuan et al.
In: Advanced Drug Delivery Reviews, Vol. 188, 114457, 09.2022.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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