Recent advances in cellular optogenetics for photomedicine

Bing Chen; Meihui Cui; Yuan Wang; Peng Shi; Hanjie Wang; Feng Wang

doi:10.1016/j.addr.2022.114457

Recent advances in cellular optogenetics for photomedicine

Bing Chen (Co-first Author), Meihui Cui (Co-first Author), Yuan Wang (Co-first Author), Peng Shi^*, Hanjie Wang, Feng Wang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

12 Citations (Scopus)

107 Downloads (CityUHK Scholars)

Abstract

Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulating neural circuits. In an optogenetic system, optical stimulation can be precisely delivered to brain tissue to achieve regulation of cellular electrical activity with unprecedented spatio-temporal resolution in living organisms. In recent years, the development of various optical actuators and novel light-delivery techniques has greatly expanded the scope of optogenetics, enabling the control of other signal pathways in non-neuronal cells for different biomedical applications, such as phototherapy and immunotherapy. This review focuses on the recent advances in optogenetic regulation of cellular activities for photomedicine. We discuss emerging optogenetic tools and light-delivery platforms, along with a survey of optogenetic execution in mammalian and microbial cells.

Original language	English
Article number	114457
Journal	Advanced Drug Delivery Reviews
Volume	188
Online published	16 Jul 2022
DOIs	https://doi.org/10.1016/j.addr.2022.114457
Publication status	Published - Sept 2022

Funding

This work was supported by the Research Grants Council of Hong Kong (Nos. 11210020, 11205219, RFS2021-1S03, and C5110-20G).

Research Keywords

Light delivery
Neuronal regulation
Optogenetic tools
Phototherapy
Signaling pathways

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.

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title = "Recent advances in cellular optogenetics for photomedicine",

abstract = "Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulating neural circuits. In an optogenetic system, optical stimulation can be precisely delivered to brain tissue to achieve regulation of cellular electrical activity with unprecedented spatio-temporal resolution in living organisms. In recent years, the development of various optical actuators and novel light-delivery techniques has greatly expanded the scope of optogenetics, enabling the control of other signal pathways in non-neuronal cells for different biomedical applications, such as phototherapy and immunotherapy. This review focuses on the recent advances in optogenetic regulation of cellular activities for photomedicine. We discuss emerging optogenetic tools and light-delivery platforms, along with a survey of optogenetic execution in mammalian and microbial cells.",

keywords = "Light delivery, Neuronal regulation, Optogenetic tools, Phototherapy, Signaling pathways",

author = "Bing Chen and Meihui Cui and Yuan Wang and Peng Shi and Hanjie Wang and Feng Wang",

year = "2022",

month = sep,

doi = "10.1016/j.addr.2022.114457",

language = "English",

volume = "188",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Recent advances in cellular optogenetics for photomedicine

AU - Chen, Bing

AU - Cui, Meihui

AU - Wang, Yuan

AU - Shi, Peng

AU - Wang, Hanjie

AU - Wang, Feng

PY - 2022/9

Y1 - 2022/9

N2 - Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulating neural circuits. In an optogenetic system, optical stimulation can be precisely delivered to brain tissue to achieve regulation of cellular electrical activity with unprecedented spatio-temporal resolution in living organisms. In recent years, the development of various optical actuators and novel light-delivery techniques has greatly expanded the scope of optogenetics, enabling the control of other signal pathways in non-neuronal cells for different biomedical applications, such as phototherapy and immunotherapy. This review focuses on the recent advances in optogenetic regulation of cellular activities for photomedicine. We discuss emerging optogenetic tools and light-delivery platforms, along with a survey of optogenetic execution in mammalian and microbial cells.

AB - Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulating neural circuits. In an optogenetic system, optical stimulation can be precisely delivered to brain tissue to achieve regulation of cellular electrical activity with unprecedented spatio-temporal resolution in living organisms. In recent years, the development of various optical actuators and novel light-delivery techniques has greatly expanded the scope of optogenetics, enabling the control of other signal pathways in non-neuronal cells for different biomedical applications, such as phototherapy and immunotherapy. This review focuses on the recent advances in optogenetic regulation of cellular activities for photomedicine. We discuss emerging optogenetic tools and light-delivery platforms, along with a survey of optogenetic execution in mammalian and microbial cells.

KW - Light delivery

KW - Neuronal regulation

KW - Optogenetic tools

KW - Phototherapy

KW - Signaling pathways

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U2 - 10.1016/j.addr.2022.114457

DO - 10.1016/j.addr.2022.114457

M3 - RGC 21 - Publication in refereed journal

C2 - 35843507

SN - 0169-409X

VL - 188

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

M1 - 114457

ER -

Recent advances in cellular optogenetics for photomedicine

Abstract

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Research Keywords

Publisher's Copyright Statement

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CRF-ExtU-Lead: Multi-level Synergistic COVID-19 Point-of-care Diagnostics Based on Upconversion Luminescence Biosensing Platform

RFS: Controlled Synthesis of Lanthanide-Doped Semiconductor Heterostructures for Flexible Display Through High-Field Electroluminescence

GRF: Developing Stretchable Multicolor Mechanoluminescent Composites with High Flexibility and Durability

Cite this

Recent advances in cellular optogenetics for photomedicine

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

CRF-ExtU-Lead: Multi-level Synergistic COVID-19 Point-of-care Diagnostics Based on Upconversion Luminescence Biosensing Platform

RFS: Controlled Synthesis of Lanthanide-Doped Semiconductor Heterostructures for Flexible Display Through High-Field Electroluminescence

GRF: Developing Stretchable Multicolor Mechanoluminescent Composites with High Flexibility and Durability

Cite this