REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR

Dinh-Tuan Phan; Lin Jin; Shofarul Wustoni; Chia-Hung Chen

REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR

Dinh-Tuan Phan
, Lin Jin
, Shofarul Wustoni
, Chia-Hung Chen^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

2 Citations (Scopus)

Abstract

This paper presents a novel biosensor enabling long term continuously monitoring bio-molecule concentrations (i.e., adenosine triphosphate - ATP) in human serum by combining the aptamer probes and a nanofluidic device. This integration is synergic: the aptamer sensor is used to measure biomolecules by binding assay, triggering fluorescence signal change, while the nanofluidic device is applied to approach real-time signal regeneration based on blocking or allowing the target molecules flow through aptamer sensor part periodically.

Original language	English
Title of host publication	μTAS 2017
Subtitle of host publication	The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	203-204
ISBN (Electronic)	9780692941836
Publication status	Published - Oct 2017
Externally published	Yes
Event	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) - Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017 https://archive.cbmsociety.org/utas/uTAS2017.zip

Publication series

Name	International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS
Publisher	Chemical and Biological Microsystems Society
ISSN (Electronic)	1556-5904

Conference

Conference	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
Place	United States
City	Savannah
Period	22/10/17 → 26/10/17
Internet address	https://archive.cbmsociety.org/utas/uTAS2017.zip

Research Keywords

Aptamer
Ion concentration polarization
Nanofluidics

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Phan, D.-T., Jin, L., Wustoni, S., & Chen, C.-H. (2017). REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR. In μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 203-204). (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS). Chemical and Biological Microsystems Society.

Phan, Dinh-Tuan ; Jin, Lin ; Wustoni, Shofarul et al. / REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR. μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2017. pp. 203-204 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

@inproceedings{22b4103a9229429ca6ef07c37cd8c49b,

title = "REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR",

abstract = "This paper presents a novel biosensor enabling long term continuously monitoring bio-molecule concentrations (i.e., adenosine triphosphate - ATP) in human serum by combining the aptamer probes and a nanofluidic device. This integration is synergic: the aptamer sensor is used to measure biomolecules by binding assay, triggering fluorescence signal change, while the nanofluidic device is applied to approach real-time signal regeneration based on blocking or allowing the target molecules flow through aptamer sensor part periodically.",

keywords = "Aptamer, Ion concentration polarization, Nanofluidics",

author = "Dinh-Tuan Phan and Lin Jin and Shofarul Wustoni and Chia-Hung Chen",

year = "2017",

month = oct,

language = "English",

series = "International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS",

publisher = "Chemical and Biological Microsystems Society",

pages = "203--204",

booktitle = "μTAS 2017",

note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) ; Conference date: 22-10-2017 Through 26-10-2017",

url = "https://archive.cbmsociety.org/utas/uTAS2017.zip",

}

Phan, D-T, Jin, L, Wustoni, S & Chen, C-H 2017, REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR. in μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS, Chemical and Biological Microsystems Society, pp. 203-204, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Savannah, Georgia, United States, 22/10/17.

REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR. / Phan, Dinh-Tuan; Jin, Lin; Wustoni, Shofarul et al.
μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2017. p. 203-204 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR

AU - Phan, Dinh-Tuan

AU - Jin, Lin

AU - Wustoni, Shofarul

AU - Chen, Chia-Hung

PY - 2017/10

Y1 - 2017/10

N2 - This paper presents a novel biosensor enabling long term continuously monitoring bio-molecule concentrations (i.e., adenosine triphosphate - ATP) in human serum by combining the aptamer probes and a nanofluidic device. This integration is synergic: the aptamer sensor is used to measure biomolecules by binding assay, triggering fluorescence signal change, while the nanofluidic device is applied to approach real-time signal regeneration based on blocking or allowing the target molecules flow through aptamer sensor part periodically.

AB - This paper presents a novel biosensor enabling long term continuously monitoring bio-molecule concentrations (i.e., adenosine triphosphate - ATP) in human serum by combining the aptamer probes and a nanofluidic device. This integration is synergic: the aptamer sensor is used to measure biomolecules by binding assay, triggering fluorescence signal change, while the nanofluidic device is applied to approach real-time signal regeneration based on blocking or allowing the target molecules flow through aptamer sensor part periodically.

KW - Aptamer

KW - Ion concentration polarization

KW - Nanofluidics

UR - https://www.scopus.com/pages/publications/85079654007

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85079654007&origin=recordpage

M3 - RGC 32 - Refereed conference paper (with host publication)

T3 - International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

SP - 203

EP - 204

BT - μTAS 2017

PB - Chemical and Biological Microsystems Society

T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)

Y2 - 22 October 2017 through 26 October 2017

ER -

Phan DT, Jin L, Wustoni S, Chen CH. REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR. In μTAS 2017: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2017. p. 203-204. (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

REAL-TIME ATP MONITORING IN HUMAN SERUM BY A NANOFLUIDIC DEVICE INTEGRATED WITH AN APTAMER SENSOR

Abstract

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Research Keywords

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