Rat calvaria osteoblast behavior and antibacterial properties of O2 and N2 plasma-implanted biodegradable poly(butylene succinate)

Huaiyu Wang; Junhui Ji; Wei Zhang; Wei Wang; Yihe Zhang; Zhengwei Wu; Yumei Zhang; Paul K. Chu

doi:10.1016/j.actbio.2009.07.026

Author(s)

Huaiyu Wang
Junhui Ji
Wei Zhang
Wei Wang
Yihe Zhang
Zhengwei Wu
Yumei Zhang

Detail(s)

Original language	English
Pages (from-to)	154-159
Journal / Publication	Acta Biomaterialia
Volume	6
Issue number	1
Publication status	Published - Jan 2010

Link(s)

DOI	DOI https://doi.org/10.1016/j.actbio.2009.07.026 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-70449701682&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(306afd35-38b6-4f71-b28e-b9933d805150).html

Abstract

Poly(butylene succinate), a novel biodegradable aliphatic polyester with excellent processability and mechanical properties, was modified by O₂ or N₂ plasma immersion ion implantation (PIII). X-ray photoelectron spectroscopy and contact angle measurements were carried out to reveal the surface characteristics of the treated and control specimens. The in vitro effects of the materials on seeded osteoblasts were detected by cell viability assay, alkaline phosphatase activity test, and real-time polymerase chain reaction analysis. Plate counting was performed to investigate the antibacterial properties. Our results show that both PIII treatments significantly improve the hydrophilicity of PBSu, and C{double bond, long}O and nitrogen groups (C{double bond, long}NH and C{single bond}NH₂) can be detected on the PBSu after O₂ and N₂ PIII, respectively. The modified samples exhibit similar compatibility to osteoblasts, which is better than that of the control, but O₂ PIII and N₂ PIII produce different effects according to the osteogenic gene expressions of seeded osteoblasts on the materials. Moreover, the N₂ plasma-modified PBSu exhibits anti-infection effects against Staphylococcus aureus and Escherichia coli but no such effects can be achieved after O₂ PIII. © 2009 Acta Materialia Inc.

Research Area(s)

ALP activity, Osteoblast, Plasma immersion ion implantation, Poly(butylene succinate), Real-time PCR

Citation Format(s)

[ RIS ] [ BibTeX ]

Rat calvaria osteoblast behavior and antibacterial properties of O₂ and N₂ plasma-implanted biodegradable poly(butylene succinate). / Wang, Huaiyu; Ji, Junhui; Zhang, Wei et al.
In: Acta Biomaterialia, Vol. 6, No. 1, 01.2010, p. 154-159.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Wang, H, Ji, J, Zhang, W, Wang, W, Zhang, Y, Wu, Z, Zhang, Y & Chu, PK 2010, 'Rat calvaria osteoblast behavior and antibacterial properties of O₂ and N₂ plasma-implanted biodegradable poly(butylene succinate)', Acta Biomaterialia, vol. 6, no. 1, pp. 154-159. https://doi.org/10.1016/j.actbio.2009.07.026

Wang, H., Ji, J., Zhang, W., Wang, W., Zhang, Y., Wu, Z., Zhang, Y., & Chu, P. K. (2010). Rat calvaria osteoblast behavior and antibacterial properties of O₂ and N₂ plasma-implanted biodegradable poly(butylene succinate). Acta Biomaterialia, 6(1), 154-159. https://doi.org/10.1016/j.actbio.2009.07.026

Wang H, Ji J, Zhang W, Wang W, Zhang Y, Wu Z et al. Rat calvaria osteoblast behavior and antibacterial properties of O₂ and N₂ plasma-implanted biodegradable poly(butylene succinate). Acta Biomaterialia. 2010 Jan;6(1):154-159. doi: 10.1016/j.actbio.2009.07.026

Wang, Huaiyu ; Ji, Junhui ; Zhang, Wei et al. / Rat calvaria osteoblast behavior and antibacterial properties of O₂ and N₂ plasma-implanted biodegradable poly(butylene succinate). In: Acta Biomaterialia. 2010 ; Vol. 6, No. 1. pp. 154-159.