Rare-earth-incorporated polymeric vector for enhanced gene delivery
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 479-488 |
| Journal / Publication | Biomaterials |
| Volume | 35 |
| Issue number | 1 |
| Online published | 5 Oct 2013 |
| Publication status | Published - Jan 2014 |
Link(s)
Abstract
Cationic polymer PEI-CyD is doped with Nd by plasma technology to produce the gene vector: Nd@PEI-CyD. Luciferase expression and EGFP transfection experiments performed in vitro reveal that Nd@PEI-CyD has significantly higher transfection efficiency than lipofectamine 2000 and PEI-CyD and the mechanism is studied and proposed. The rare-earth element, Nd, stimulates the energy metabolism of cells, enhances cell uptake of complexes/pDNA, and regulates the cellular pathways. These special features suggest a new strategy involving metal-incorporated non-viral gene vectors.
Research Area(s)
- Cellular pathways, Energetic ions, Neodymium, PEI-CyD, Plasma treatment
Citation Format(s)
Rare-earth-incorporated polymeric vector for enhanced gene delivery. / Wang, Qiwen; Jin, Weihong; Wu, Guosong et al.
In: Biomaterials, Vol. 35, No. 1, 01.2014, p. 479-488.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
