Rare-earth-incorporated polymeric vector for enhanced gene delivery

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Qiwen Wang
  • Weihong Jin
  • Guosong Wu
  • Ying Zhao
  • Xue Jin
  • Xiurong Hu
  • Jun Zhou
  • Guping Tang

Detail(s)

Original languageEnglish
Pages (from-to)479-488
Journal / PublicationBiomaterials
Volume35
Issue number1
Online published5 Oct 2013
Publication statusPublished - Jan 2014

Abstract

Cationic polymer PEI-CyD is doped with Nd by plasma technology to produce the gene vector: Nd@PEI-CyD. Luciferase expression and EGFP transfection experiments performed in vitro reveal that Nd@PEI-CyD has significantly higher transfection efficiency than lipofectamine 2000 and PEI-CyD and the mechanism is studied and proposed. The rare-earth element, Nd, stimulates the energy metabolism of cells, enhances cell uptake of complexes/pDNA, and regulates the cellular pathways. These special features suggest a new strategy involving metal-incorporated non-viral gene vectors.

Research Area(s)

  • Cellular pathways, Energetic ions, Neodymium, PEI-CyD, Plasma treatment

Citation Format(s)

Rare-earth-incorporated polymeric vector for enhanced gene delivery. / Wang, Qiwen; Jin, Weihong; Wu, Guosong; Zhao, Ying; Jin, Xue; Hu, Xiurong; Zhou, Jun; Tang, Guping; Chu, Paul K.

In: Biomaterials, Vol. 35, No. 1, 01.2014, p. 479-488.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review