Rapid screening of potential metallic glasses for biomedical applications

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

29 Scopus Citations
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Author(s)

  • C.H. Lin
  • C.H. Huang
  • J.F. Chuang
  • J.S.C. Jang
  • C.H. Chen

Detail(s)

Original languageEnglish
Pages (from-to)4520-4526
Journal / PublicationMaterials Science and Engineering C
Volume33
Issue number8
Online published12 Jul 2013
Publication statusPublished - 1 Dec 2013
Externally publishedYes

Abstract

This paper presents a rapid screening process to select potential titanium and zirconium based metallic glasses (MGs) for bio-material applications. Electrochemical activity of 7 MGs including 6 bulk metallic glasses and 1 thin-film deposited MG in simulation body and human serum is first inspected. A lowvoltage potential state test is also developed to simulate the cell membrane potential that the implant MGs will suffer. Results show that the MGs composed of Ti65Si15Ta10Zr10 and Ta57Zr23Cu12Ti8 exhibit excellent electrochemical stability in both simulation body fluid and human serum. In addition, the copper content in the MGs plays an important role on the electrochemical activity. MGs with the copper content higher than 17.5% show significant electrochemical responses. The cytotoxicity of the solid MG samples and the corrosion released ions are also evaluated by an in-vitro MTT test utilizing the murine bone marrow stem cells. Results indicate that all the solid MG samples show no acute cytotoxicity yet the corrosion released ions show significant toxicity for murine bone marrow stem cells. The rapid screening process developed in the present study suggests that the Ti65Si15Ta10Zr10 metallic glass has high potential for biomedical applications due to its good electrochemical stability and very low cytotoxicity.

Research Area(s)

  • Cytotoxicity, Electrochemical activity, Metallic glasses, MTT test, Potential state

Citation Format(s)

Rapid screening of potential metallic glasses for biomedical applications. / Lin, C.H.; Huang, C.H.; Chuang, J.F. et al.
In: Materials Science and Engineering C, Vol. 33, No. 8, 01.12.2013, p. 4520-4526.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review