Rapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectrometry determination

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Qingling Li
  • Michael H.W. Lam
  • Rudolf S.S. Wu
  • Biwang Jiang

Detail(s)

Original languageEnglish
Pages (from-to)1219-1226
Journal / PublicationJournal of Chromatography A
Volume1217
Issue number8
Publication statusPublished - 19 Feb 2010

Abstract

A new Fe3O4/poly(divinylbenzene-co-methacrylic acid) core-shell magnetite microspheric material have been successfully developed as magnetic-mediated solid-phase extraction micro-particle sorbent in dispersion mode (MM-SPE-MP) for the determination of selected estrogenic endocrine disrupting chemicals (EDCs), namely: estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethynylestradiol (EE2) and bisphenol-A (BPA), in natural water, via quantification by HPLC tandem mass spectrometry. The magnetite Fe3O4 core of this MM-SPE-MP sorbent was fabricated by a solvothermal approach and the thin layer of amphipolar poly(divinylbenzene-co-methacrylic acid) (pDVB-MAA) coating was established via suspension polymerization. The resultant core-shell MM-SPE-MP sorbent material was characterized by electron microscopy, X-ray diffraction and Fourier-transformed infrared spectroscopy. Particle size distribution of the core-shell microspheres was within the range 300-700 nm in diameter and the thickness of the pDVB-MAA coating was ca. 10 nm. This magnetite microspheric material can be easily dispersed in aqueous samples and retrieved by the application of external magnetic field via a small piece of permanent magnet. The MM-SPE-MP process for the selected estrogenic EDCs involved the dispersion of the core-shell microspheric sorbent in water samples with sonication, followed by magnetic aided retrieval of the sorbent and solvent (methanol) desorption of extracted EDCs for LC-MS/MS analysis. Partition equilibrium for all the selected EDCs onto this MM-SPE-MP sorbent was achieved within 15 min. Recoveries of the EDCs were in ranges of 56-111%. Analytes with smaller KOW value showed relatively lower recovery (and relatively longer equilibration time for partitioning). Method detection limits achieved were found to be 1-36 pg ml-1 (n = 3), while the repeatability was 6-34% (p <0.05, n = 3). This work demonstrates the usefulness of MM-SPE-MP in the rapid and highly sensitive monitoring of trace organic contaminants in natural waters. © 2009 Elsevier B.V. All rights reserved.

Research Area(s)

  • Core-shell microspheres, Endocrine disrupting chemicals, Estrogen mimics, Magnetite microspheres, Solid-phase extraction

Citation Format(s)

Rapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectrometry determination. / Li, Qingling; Lam, Michael H.W.; Wu, Rudolf S.S.; Jiang, Biwang.

In: Journal of Chromatography A, Vol. 1217, No. 8, 19.02.2010, p. 1219-1226.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review