Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system

Jinglun Li; Ko-Wei Chang; Ching-Hsuan Yang; Shu-Chu Shiesh; Gwo-Bin Lee

Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system

Jinglun Li
, Ko-Wei Chang
, Ching-Hsuan Yang
, Shu-Chu Shiesh
, Gwo-Bin Lee

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

3 Citations (Scopus)

Abstract

Diabetes requires an on-site routine monitoring on a daily basis. In this study, a compact, integrated microfluidic system capable of rapidly measuring the value of glycated hemoglobin (HbA_1c) was reported. Since nucleic-acid aptamers with high sensitivity and specificity to hemoglobin and HbA_1c were used, the two-aptamer assay can perform the detection of HbA_1c within a short period of time. Furthermore, the microfluidic system is extended to parallel processing such that multiple assays can be realized on a single chip. Therefore, it may be promising for providing a diagnostic device for diabetes patients in the near future.

Original language	English
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	1951-1953
ISBN (Print)	9780979806476
Publication status	Published - 2014
Externally published	Yes
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) - San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014

Publication series

Name	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Place	United States
City	San Antonio
Period	26/10/14 → 30/10/14

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Aptamer
Diabetes mellitus
HbA<inf>1c</inf>
Microfluidics

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Li, J., Chang, K.-W., Yang, C.-H., Shiesh, S.-C., & Lee, G.-B. (2014). Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 1951-1953). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.

Li, Jinglun ; Chang, Ko-Wei ; Yang, Ching-Hsuan et al. / Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 1951-1953 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

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title = "Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system",

abstract = "Diabetes requires an on-site routine monitoring on a daily basis. In this study, a compact, integrated microfluidic system capable of rapidly measuring the value of glycated hemoglobin (HbA1c) was reported. Since nucleic-acid aptamers with high sensitivity and specificity to hemoglobin and HbA1c were used, the two-aptamer assay can perform the detection of HbA1c within a short period of time. Furthermore, the microfluidic system is extended to parallel processing such that multiple assays can be realized on a single chip. Therefore, it may be promising for providing a diagnostic device for diabetes patients in the near future.",

keywords = "Aptamer, Diabetes mellitus, HbA<inf>1c</inf>, Microfluidics",

author = "Jinglun Li and Ko-Wei Chang and Ching-Hsuan Yang and Shu-Chu Shiesh and Gwo-Bin Lee",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) ; Conference date: 26-10-2014 Through 30-10-2014",

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language = "English",

isbn = "9780979806476",

series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

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Li, J, Chang, K-W, Yang, C-H, Shiesh, S-C & Lee, G-B 2014, Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, pp. 1951-1953, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014), San Antonio, Texas, United States, 26/10/14.

Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. / Li, Jinglun; Chang, Ko-Wei; Yang, Ching-Hsuan et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 1951-1953 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system

AU - Li, Jinglun

AU - Chang, Ko-Wei

AU - Yang, Ching-Hsuan

AU - Shiesh, Shu-Chu

AU - Lee, Gwo-Bin

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2014

Y1 - 2014

N2 - Diabetes requires an on-site routine monitoring on a daily basis. In this study, a compact, integrated microfluidic system capable of rapidly measuring the value of glycated hemoglobin (HbA1c) was reported. Since nucleic-acid aptamers with high sensitivity and specificity to hemoglobin and HbA1c were used, the two-aptamer assay can perform the detection of HbA1c within a short period of time. Furthermore, the microfluidic system is extended to parallel processing such that multiple assays can be realized on a single chip. Therefore, it may be promising for providing a diagnostic device for diabetes patients in the near future.

AB - Diabetes requires an on-site routine monitoring on a daily basis. In this study, a compact, integrated microfluidic system capable of rapidly measuring the value of glycated hemoglobin (HbA1c) was reported. Since nucleic-acid aptamers with high sensitivity and specificity to hemoglobin and HbA1c were used, the two-aptamer assay can perform the detection of HbA1c within a short period of time. Furthermore, the microfluidic system is extended to parallel processing such that multiple assays can be realized on a single chip. Therefore, it may be promising for providing a diagnostic device for diabetes patients in the near future.

KW - Aptamer

KW - Diabetes mellitus

KW - HbA<inf>1c</inf>

KW - Microfluidics

UR - https://www.scopus.com/pages/publications/84941660668

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84941660668&origin=recordpage

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9780979806476

T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

SP - 1951

EP - 1953

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)

Y2 - 26 October 2014 through 30 October 2014

ER -

Li J, Chang KW, Yang CH, Shiesh SC, Lee GB. Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 1951-1953. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Research Keywords

Other Access Options

Permanent Link

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Cite this