Radiation-induced rescue effect

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

13 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)163-170
Journal / PublicationJournal of Radiation Research
Volume60
Issue number2
Online published8 Jan 2019
Publication statusPublished - Mar 2019

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Abstract

Radiation-induced rescue effect (RIRE) refers to the phenomenon in which detrimental effects in targeted irradiated cells are reduced upon receiving feedback signals from partnered non-irradiated bystander cells, or from the medium previously conditioning these partnered non-irradiated bystander cells. For convenience, in the current review we define two types of RIRE: (i) Type 1 RIRE (reduced detrimental effects in targeted cells upon receiving feedback signals from bystander cells) and (ii) Type 2 RIRE (exacerbated detrimental effects in targeted cells upon receiving feedback signals from bystander cells). The two types of RIRE, as well as the associated mechanisms and chemical messengers, have been separately reviewed. The recent report on the potential effects of RIRE on the traditional colony-formation assays has also been reviewed. Finally, future priorities and directions for research into RIRE are discussed.

Research Area(s)

  • radiation-induced rescue effect, radiation-induced bystander effect, bilateral bystander responses, reciprocal bystander effect, NF-KAPPA-B, INDUCED BYSTANDER, NITRIC-OXIDE, CELL-SURVIVAL, UNIRRADIATED CELLS, CANCER, INDUCTION, ACTIVATION, RESPONSES, P21(RAS)

Citation Format(s)

Radiation-induced rescue effect. / Yu, Kwan Ngok.

In: Journal of Radiation Research, Vol. 60, No. 2, 03.2019, p. 163-170.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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