Radiation-induced bystander effect : Early process and rapid assessment

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Hongzhi Wang
  • K. N. Yu
  • Jue Hou
  • Qian Liu
  • Wei Han

Detail(s)

Original languageEnglish
Pages (from-to)137-144
Journal / PublicationCancer Letters
Volume356
Issue number1
Online published15 Oct 2013
Publication statusPublished - 1 Jan 2015

Abstract

Radiation-induced bystander effect (RIBE) is a biological process that has received attention over the past two decades. RIBE refers to a plethora of biological effects in non-irradiated cells, including induction of genetic damages, gene expression, cell transformation, proliferation and cell death, which are initiated by receiving bystander signals released from irradiated cells. RIBE brings potential hazards to normal tissues in radiotherapy, and imparts a higher risk from low-dose radiation than we previously thought. Detection with proteins related to DNA damage and repair, cell cycle control, proliferation, etc. have enabled rapid assessment of RIBE in a number of research systems such as cultured cells, three-dimensional tissue models and animal models. Accumulated experimental data have suggested that RIBE may be initiated rapidly within a time frame as short as several minutes after radiation. These have led to the requirement of techniques capable of rapidly assessing RIBE itself as well as assessing the early processes involved.

Research Area(s)

  • Early process, Radiation-induced bystander effect, Rapid assessment

Citation Format(s)

Radiation-induced bystander effect : Early process and rapid assessment. / Wang, Hongzhi; Yu, K. N.; Hou, Jue; Liu, Qian; Han, Wei.

In: Cancer Letters, Vol. 356, No. 1, 01.01.2015, p. 137-144.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review