Abstract
Radiation-induced rescue effect (RIRE) refers to the phenomenon in which detrimental effects in targeted irradiated cells are reduced upon receiving feedback signals from partnered non-irradiated bystander cells, or from the medium previously conditioning these partnered non-irradiated bystander cells. For convenience, in the current review we define two types of RIRE: (i) Type 1 RIRE (reduced detrimental effects in targeted cells upon receiving feedback signals from bystander cells) and (ii) Type 2 RIRE (exacerbated detrimental effects in targeted cells upon receiving feedback signals from bystander cells). The two types of RIRE, as well as the associated mechanisms and chemical messengers, have been separately reviewed. The recent report on the potential effects of RIRE on the traditional colony-formation assays has also been reviewed. Finally, future priorities and directions for research into RIRE are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 163-170 |
| Journal | Journal of Radiation Research |
| Volume | 60 |
| Issue number | 2 |
| Online published | 8 Jan 2019 |
| DOIs | |
| Publication status | Published - Mar 2019 |
Funding
Funding for the publication of this article in open access was provided by the project IRF/0024 from the State Key Laboratory in Marine Pollution of the City University of Hong Kong.
Research Keywords
- radiation-induced rescue effect
- radiation-induced bystander effect
- bilateral bystander responses
- reciprocal bystander effect
- NF-KAPPA-B
- INDUCED BYSTANDER
- NITRIC-OXIDE
- CELL-SURVIVAL
- UNIRRADIATED CELLS
- CANCER
- INDUCTION
- ACTIVATION
- RESPONSES
- P21(RAS)
Publisher's Copyright Statement
- This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/