Quinoline based reversible fluorescent probe for Pb2+; applications in milk, bioimaging and INHIBIT molecular logic gate

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • K. Velmurugan
  • R. Vickram
  • R. Karthick
  • G. Prabakaran
  • S. Suresh
  • J. Prabhu
  • G. Velraj
  • L. Tang
  • R. Nandhakumar

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number129098
Journal / PublicationFood Chemistry
Volume348
Online published18 Jan 2021
Publication statusPublished - 30 Jun 2021

Abstract

We report the modular design and synthesis of an amine dangled Schiff base quinoline–morpholine conjugate (QMC) for highly selective detection of Pb2+ ions via fluorimetry. The sensing strategy of QMC towards Pb2+ ion exhibits a large blue shift with fluorescent enhancement via the intramolecular charge transfer (ICT) process. At the same time, QMC coordination with Pb2+, the C-N single bond rotation between quinoline and morpholine rings and the C=N isomerization process were blocked. Best of our knowledge, this is the first blue shifted turn-on fluorescent chemosensor for Pb2+ ion via the ICT process. Furthermore, QMC selectively detects Pb2+ ion without any interference with alkali, alkaline earth, and transition metal ions, and limit of detection (LOD) downs to 13 μM, which is a permissible level of Pb2+ ion in drinking water reported by WHO. The 1:2 binding stoichiometry between QMC and Pb2+ was confirmed by fluorimetric, 1H NMR titration, mass spectrometry, and theoretical studies. Finally, QMC was potentially applied for the sensing of Pb2+ ions in milk, red wine, live cells and an INHIBIT molecular logic function was constructed by using Pb2+ and EDTA as chemical inputs.

Research Area(s)

  • Bioimaging, Fluorescence, ICT, Lead, Milk detection, Quinoline

Citation Format(s)

Quinoline based reversible fluorescent probe for Pb2+; applications in milk, bioimaging and INHIBIT molecular logic gate. / Velmurugan, K.; Vickram, R.; Jipsa, C. V. et al.
In: Food Chemistry, Vol. 348, 129098, 30.06.2021.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review