Quinoline based reversible fluorescent probe for Pb2+; applications in milk, bioimaging and INHIBIT molecular logic gate
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Article number | 129098 |
Journal / Publication | Food Chemistry |
Volume | 348 |
Online published | 18 Jan 2021 |
Publication status | Published - 30 Jun 2021 |
Link(s)
Abstract
We report the modular design and synthesis of an amine dangled Schiff base quinoline–morpholine conjugate (QMC) for highly selective detection of Pb2+ ions via fluorimetry. The sensing strategy of QMC towards Pb2+ ion exhibits a large blue shift with fluorescent enhancement via the intramolecular charge transfer (ICT) process. At the same time, QMC coordination with Pb2+, the C-N single bond rotation between quinoline and morpholine rings and the C=N isomerization process were blocked. Best of our knowledge, this is the first blue shifted turn-on fluorescent chemosensor for Pb2+ ion via the ICT process. Furthermore, QMC selectively detects Pb2+ ion without any interference with alkali, alkaline earth, and transition metal ions, and limit of detection (LOD) downs to 13 μM, which is a permissible level of Pb2+ ion in drinking water reported by WHO. The 1:2 binding stoichiometry between QMC and Pb2+ was confirmed by fluorimetric, 1H NMR titration, mass spectrometry, and theoretical studies. Finally, QMC was potentially applied for the sensing of Pb2+ ions in milk, red wine, live cells and an INHIBIT molecular logic function was constructed by using Pb2+ and EDTA as chemical inputs.
Research Area(s)
- Bioimaging, Fluorescence, ICT, Lead, Milk detection, Quinoline
Citation Format(s)
Quinoline based reversible fluorescent probe for Pb2+; applications in milk, bioimaging and INHIBIT molecular logic gate. / Velmurugan, K.; Vickram, R.; Jipsa, C. V. et al.
In: Food Chemistry, Vol. 348, 129098, 30.06.2021.
In: Food Chemistry, Vol. 348, 129098, 30.06.2021.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review