Quantitative characterization of mechano-biological interrelationships of single cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Detail(s)

Original languageEnglish
Pages (from-to)4967-4972
Journal / PublicationInternational Journal of Advanced Manufacturing Technology
Volume105
Issue number12
Online published26 Nov 2019
Publication statusPublished - Dec 2019

Abstract

This paper presented a quantitative investigation on the alteration of cell biological functions in relation to the change of mechanical properties of single cells. Leukemia NB4 cells were used as cell line. The dielectrophoresis (DEP) method was utilized to verify the mechanical properties variation of NB4 cells under the electric field treatment. A quantitative study of cell mechanical properties was then carried out using optical tweezers (OT), and cell biological properties using gene expression measurement. The result shows cell stiffness decreased after electric treatment. Biological properties related to cell motility, structure, apoptosis, migration, invasion, and metastases changed with cell mechanical properties variation.

Research Area(s)

  • Dielectrophoresis, Mechano-biological interrelationship, Optical tweezers, Quantitative investigation