Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

Hao Yang; Xue Gou; Henry Chu; Yong Wang; Dong Sun

doi:10.1109/NANO.2014.6968077

Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

Hao Yang, Xue Gou, Henry Chu, Yong Wang, Dong Sun^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.

Original language	English
Title of host publication	14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014
Publisher	IEEE
Pages	742-746
ISBN (Print)	9781479956227
DOIs	https://doi.org/10.1109/NANO.2014.6968077
Publication status	Published - 26 Nov 2014
Event	14th IEEE International Conference on Nanotechnology (IEEE-NANO 2014) - Toronto, Canada Duration: 18 Aug 2014 → 21 Aug 2014

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Conference	14th IEEE International Conference on Nanotechnology (IEEE-NANO 2014)
Country/Territory	Canada
City	Toronto
Period	18/08/14 → 21/08/14

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10.1109/NANO.2014.6968077

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@inproceedings{893418b1db814c099ee232f4a81ad13e,

title = "Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design",

abstract = "Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.",

author = "Hao Yang and Xue Gou and Henry Chu and Yong Wang and Dong Sun",

year = "2014",

month = nov,

day = "26",

doi = "10.1109/NANO.2014.6968077",

language = "English",

isbn = "9781479956227",

pages = "742--746",

booktitle = "14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014",

publisher = "IEEE",

address = "United States",

note = "14th IEEE International Conference on Nanotechnology (IEEE-NANO 2014) ; Conference date: 18-08-2014 Through 21-08-2014",

}

Yang, H, Gou, X, Chu, H, Wang, Y & Sun, D 2014, Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design. in 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014., 6968077, IEEE, pp. 742-746, 14th IEEE International Conference on Nanotechnology (IEEE-NANO 2014), Toronto, Canada, 18/08/14. https://doi.org/10.1109/NANO.2014.6968077

Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design. / Yang, Hao; Gou, Xue; Chu, Henry et al.
14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014. IEEE, 2014. p. 742-746 6968077.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

AU - Yang, Hao

AU - Gou, Xue

AU - Chu, Henry

AU - Wang, Yong

AU - Sun, Dong

PY - 2014/11/26

Y1 - 2014/11/26

N2 - Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.

AB - Cell chemotaxis is a phenomenon in which cells spatially sense the chemoattractant gradient in the extra-environment and move along this gradient. This paper illustrates the relationship between the chemoattractant gradient and the cell velocity quantitatively, using a single-cell motility assay method based on optically manipulated microsources. A case study was performed on leukemia cancer cells. Quantitative study indicates that the cell is sensitive to the gradient, and can move faster under a high gradient. Based on the quantitative relationship, a control strategy was proposed to realize automatically induced cell migration. The simulation results demonstrate the effectiveness and robustness of the proposed method.

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DO - 10.1109/NANO.2014.6968077

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781479956227

SP - 742

EP - 746

BT - 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014

PB - IEEE

T2 - 14th IEEE International Conference on Nanotechnology (IEEE-NANO 2014)

Y2 - 18 August 2014 through 21 August 2014

ER -

Quantitative analysis of chemoattractant gradient induced cell migration velocity and automatic controller design

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