Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Christine M. Wright
  • Raj J. Chovatiya
  • Nora E. Jameson
  • David M. Turner
  • Stefan Werner
  • Donna M. Huryn
  • James M. Pipas
  • Billy W. Day
  • Peter Wipf
  • Jeffrey L. Brodsky

Detail(s)

Original languageEnglish
Pages (from-to)3291-3301
Journal / PublicationBioorganic and Medicinal Chemistry
Volume16
Issue number6
Publication statusPublished - 15 Mar 2008
Externally publishedYes

Abstract

The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. © 2007 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Apoptosis, ATP, ATPase, Biginelli, Chaperone, Dihydropyrimidinone, Hsp40, Hsp70, J domain, SK-BR-3, SV40, T antigen, Tetrahydropyrimidinone, Ugi

Citation Format(s)

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. / Wright, Christine M.; Chovatiya, Raj J.; Jameson, Nora E.; Turner, David M.; Zhu, Guangyu; Werner, Stefan; Huryn, Donna M.; Pipas, James M.; Day, Billy W.; Wipf, Peter; Brodsky, Jeffrey L.

In: Bioorganic and Medicinal Chemistry, Vol. 16, No. 6, 15.03.2008, p. 3291-3301.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal