Purification of phenylethanoids from Brandisia hancei and the antiproliferative effects on aortic smooth muscle

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Z. D. He
  • X. Yao
  • C. W. Lau
  • W. I. Law
  • Z. Y. Chen

Detail(s)

Original languageEnglish
Pages (from-to)520-522
Journal / PublicationPlanta Medica
Volume67
Issue number6
Publication statusPublished - 2001
Externally publishedYes

Abstract

The present study describes the isolation and purification of acteoside, 2′-acetylacteoside, poliumoside and brandioside, four phenylethanoid glycosides from Brandisia hancei. We examined their effects on the proliferation of cultured A7r5 rat aortic smooth muscle cells. The proliferative response was measured from the [3H]-thymidine incorporation into DNA. All four glycosides suppressed the proliferative response in the presence of 2% or 5% fetal bovine serum in a concentration-dependent manner. The rank order of effectiveness for inhibition of cell proliferation was: brandioside ≥ poliumoside > 2′-acetylacteoside ≥ acteoside. The acetyl group at position 2′ of glucose does not seem necessary for the anti-proliferative effects of acteoside and 2′-acetylacteoside, while the hydroxy groups of the aromatic rings appear to play a role. Inhibition of smooth muscle cell proliferation by phenylethanoids indicates that these compounds may have preventative effects on arteriosclerosis.

Research Area(s)

  • Aortic smooth muscle, Brandisia hancei, Phenylethanoid glycosides, Proliferation, Rat, Scrophulariaceae

Bibliographic Note

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Citation Format(s)

Purification of phenylethanoids from Brandisia hancei and the antiproliferative effects on aortic smooth muscle. / He, Z. D.; Huang, Y.; Yao, X. et al.
In: Planta Medica, Vol. 67, No. 6, 2001, p. 520-522.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review