TY - GEN
T1 - Pulsatile shear stress and high glucose concentrations induced reactive oxigen species production in endothelial cells
AU - Yu, J. Q.
AU - Chin, L. K.
AU - Fu, Y.
AU - Yu, T.
AU - Luo, K. Q.
AU - Liu, A. Q.
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 2011
Y1 - 2011
N2 - A hemodynamic Lab-on-a-chip system was developed in this study. This system has two unique features: (1) it consists of a microfluidic network with an array of endothelial cell seeding sites for testing them under multiple conditions, and (2) the flow rate and the frequency of the culture medium in the microchannel are controlled by a pulsation free pump to mimic the flow profile of the blood in the blood vessel under different physiological conditions. The results demonstrate the advantage of utilizing this system over the conventional non-pulsatile system in the future shear stress related studies. © 2011 IEEE.
AB - A hemodynamic Lab-on-a-chip system was developed in this study. This system has two unique features: (1) it consists of a microfluidic network with an array of endothelial cell seeding sites for testing them under multiple conditions, and (2) the flow rate and the frequency of the culture medium in the microchannel are controlled by a pulsation free pump to mimic the flow profile of the blood in the blood vessel under different physiological conditions. The results demonstrate the advantage of utilizing this system over the conventional non-pulsatile system in the future shear stress related studies. © 2011 IEEE.
KW - endothelial cell
KW - Hemodynamic
KW - Lab-on-a-chip
KW - reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=80052109519&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-80052109519&origin=recordpage
U2 - 10.1109/TRANSDUCERS.2011.5969310
DO - 10.1109/TRANSDUCERS.2011.5969310
M3 - RGC 32 - Refereed conference paper (with host publication)
SN - 9781457701573
T3 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
SP - 767
EP - 770
BT - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
T2 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Y2 - 5 June 2011 through 9 June 2011
ER -