Particulate-Aggregated Adhesives with Exudate-Sensitive Properties and Sustained Bacteria Disinfection to Facilitate Wound Healing

Wound-associated infections create additional suffering and come at a high cost for patients and their families, which urgently require wound disinfection biomaterials with improved healing efficacy. Here, we report an adhesive with sustained bacteria disinfection ability, which is aggregated from hydrogen-bonded polymer particulates. The particulate-aggregated adhesive shows strong binding ability on different surfaces from rigid substrates to soft skins. Moreover, water-sensitive mechanical properties are shown in wound exudates, resulting from the dissociation of hydrogen bonds under the competition of water and thus the sustained release of particulates. Synergizing with the strong binding ability, exudate-sensitive behaviors, and sustained release of antibacterial particulates, the adhesive achieves sustained bactericidal activity and can facilitate the healing process in bacteria-infected skin wounds.