Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

98 Scopus Citations
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Author(s)

  • Pengcheng Han
  • Chao Su
  • Yanfang Zhang
  • Chongzhi Bai
  • Anqi Zheng
  • Chengpeng Qiao
  • Qing Wang
  • Sheng Niu
  • Qian Chen
  • Yuqin Zhang
  • Weiwei Li
  • Hanyi Liao
  • Jing Li
  • Zengyuan Zhang
  • Heecheol Cho
  • Xiaoyu Rong
  • Yu Hu
  • Niu Huang
  • Jinghua Yan
  • Qihui Wang
  • Xin Zhao
  • George Fu Gao
  • Jianxun Qi

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Detail(s)

Original languageEnglish
Article number6103
Journal / PublicationNature Communications
Volume12
Issue number1
Online published20 Oct 2021
Publication statusPublished - Dec 2021

Link(s)

Abstract

Multiple SARS-CoV-2 variants of concern (VOCs) have been emerging and some have been linked to an increase in case numbers globally. However, there is yet a lack of understanding of the molecular basis for the interactions between the human ACE2 (hACE2) receptor and these VOCs. Here we examined several VOCs including Alpha, Beta, and Gamma, and demonstrate that five variants receptor-binding domain (RBD) increased binding affinity for hACE2, and four variants pseudoviruses increased entry into susceptible cells. Crystal structures of hACE2-RBD complexes help identify the key residues facilitating changes in hACE2 binding affinity. Additionally, soluble hACE2 protein efficiently prevent most of the variants pseudoviruses. Our findings provide important molecular information and may help the development of novel therapeutic and prophylactic agents targeting these emerging mutants.

Research Area(s)

Citation Format(s)

Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants. / Han, Pengcheng; Su, Chao; Zhang, Yanfang et al.
In: Nature Communications, Vol. 12, No. 1, 6103, 12.2021.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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