5-HT3a Receptors Modulate Hippocampal Gamma Oscillations by Regulating Synchrony of Parvalbumin-Positive Interneurons

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

19 Scopus Citations
View graph of relations

Author(s)

  • Ying Huang
  • Kristopher Yoon
  • Ho Ko
  • Song Jiao
  • Wataru Ito
  • Jian-Young Wu
  • Bai Lu
  • Alexei Morozov

Detail(s)

Original languageEnglish
Pages (from-to)576-585
Journal / PublicationCerebral Cortex
Volume26
Issue number2
Publication statusPublished - 1 Feb 2016
Externally publishedYes

Abstract

Gamma-frequency oscillatory activity plays an important role in information integration across brain areas. Disruption in gamma oscillations is implicated in cognitive impairments in psychiatric disorders, and 5-HT3 receptors (5-HT3Rs) are suggested as therapeutic targets for cognitive dysfunction in psychiatric disorders. Using a 5-HT3aR-EGFP transgenic mouse line and inducing gamma oscillations by carbachol in hippocampal slices, we show that activation of 5-HT3aRs, which are exclusively expressed in cholecystokinin (CCK)-containing interneurons, selectively suppressed and desynchronized firings in these interneurons by enhancing spike-frequency accommodation in a small conductance potassium (SK)-channel-dependent manner. Parvalbumin-positive interneurons therefore received diminished inhibitory input leading to increased but desynchronized firings of PV cells. As a consequence, the firing of pyramidal neurons was desynchronized and gamma oscillations were impaired. These effects were independent of 5-HT3aR-mediated CCK release. Our results therefore revealed an important role of 5-HT3aRs in gamma oscillations and identified a novel crosstalk among different types of interneurons for regulation of network oscillations. The functional link between 5-HT3aR and gamma oscillations may have implications for understanding the cognitive impairments in psychiatric disorders. © 2014 The Author 2014.

Research Area(s)

  • 5-HT3a receptors, CCK interneurons, Gamma oscillations, Hippocampus, PV interneurons

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

5-HT3a Receptors Modulate Hippocampal Gamma Oscillations by Regulating Synchrony of Parvalbumin-Positive Interneurons. / Huang, Ying; Yoon, Kristopher; Ko, Ho et al.
In: Cerebral Cortex, Vol. 26, No. 2, 01.02.2016, p. 576-585.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review