MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 205-210 |
Journal / Publication | Biochemical and Biophysical Research Communications |
Volume | 380 |
Issue number | 2 |
Publication status | Published - 6 Mar 2009 |
Externally published | Yes |
Link(s)
Abstract
MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules. © 2009 Elsevier Inc. All rights reserved.
Research Area(s)
- CCNE1, Cell cycle, Glioblastoma, MicroRNA, MiR-15b
Citation Format(s)
MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. / Xia, Hongping; Qi, Yanting; Ng, Samuel S. et al.
In: Biochemical and Biophysical Research Communications, Vol. 380, No. 2, 06.03.2009, p. 205-210.
In: Biochemical and Biophysical Research Communications, Vol. 380, No. 2, 06.03.2009, p. 205-210.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review