Interactions between carbon nanotubes and DNA polymerase and restriction endonucleases

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Author(s)

  • Changqing Yi
  • Chi-Chun Fong
  • Weiwei Chen
  • Suijian Qi
  • Chi-Hung Tzang
  • Shuit-Tong Lee

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number25102
Journal / PublicationNanotechnology
Volume18
Issue number2
Publication statusPublished - 17 Jan 2007

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-33846828805&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(f048c78d-cf5f-4625-b5b4-9ff68881ffa8).html

Abstract

Effects of multi-walled carbon nanotubes (MWCNT) and single-walled carbon nanotubes (SWCNT) functionalized with and without carboxylic groups on polymerase chain reaction (PCR) and restriction digestion reaction were investigated. The results showed that CNT can reduce and even inhibit PCR and restriction digestion reaction, possibly due to the decrease of respective enzyme activity. The inhibition effect on double restriction digestion reaction and PCR was increased in the order of CNT-COOH > pristine CNT and SWCNT> MWCNT. This study demonstrated that CNT may significantly affect the efficiency of biochemical reactions through different action mechanisms, which is critical for understanding how nanomaterials impact biological systems. © IOP Publishing Ltd.

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Publication fingerprints text

100
Chemical Reaction Chemistry
100
Deoxyribonucleic Ac... Chemistry
100
Chain Reaction Chemistry
100
Carbon Nanotube Chemistry
100
Digestion Chemistry
100
interactions INIS
100
carbon nanotubes INIS
100
endonucleases INIS
100
dna polymerases INIS
100
Carbon Nanotubes Keyphrases
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Citation Format(s)

[ RIS ] [ BibTeX ]
Interactions between carbon nanotubes and DNA polymerase and restriction endonucleases. / Yi, Changqing; Fong, Chi-Chun; Chen, Weiwei et al.
In: Nanotechnology, Vol. 18, No. 2, 25102, 17.01.2007.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review