Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

3 Scopus Citations
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Author(s)

  • Shi-ting Chen
  • Si-yuan He
  • Hai-jun Jin
  • Ye-yuan Zhang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number130224
Journal / PublicationMaterials Letters
Volume301
Online published8 Jun 2021
Publication statusPublished - 15 Oct 2021

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-85108268439&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(e9357a3b-b26e-45d1-8323-21f33e53cce0).html

Abstract

Nanoporous gold (NPG) is promising to functionalize as an immunoisolation membrane in cell encapsulation therapy (CET) due to its tunable pore structure. Herein, we evaluated the potential utilization of NPG membrane for the encapsulation of pancreatic islet cells, that is, a practical CET to correct the diabetic state. The results showed that the NPG membrane maintained the viability of mouse insulinoma 6 (MIN6) cells and allowed the sufficient exchange of substances for cell metabolism over 4 days. In vitro, the glucose-stimulated insulin released by encapsulated cells was detected, demonstrating the functional performance of the NPG-encapsulation.

Research Area(s)

  • Biomaterials, Cell encapsulation, Dealloying, Diabetes treatment, Nanoporous gold, Porous material

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Publication fingerprints text

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Cells Medicine and Dentistry
100
Pancreatic Islet Medicine and Dentistry
100
Nanoporous Gold Keyphrases
100
Cell Encapsulation Keyphrases
100
Pancreatic Islet Ce... Keyphrases
100
Nanoporosity Chemistry
100
membranes INIS
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gold INIS
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pancreas INIS
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encapsulation INIS
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Citation Format(s)

[ RIS ] [ BibTeX ]
Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation. / Chen, Shi-ting; He, Si-yuan; Wang, Wan-ying et al.
In: Materials Letters, Vol. 301, 130224, 15.10.2021.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review